Table 1 Influence of genetic variants on VTE in protein S, protein C, and antithrombin genes in East Asian population

 c.586A>G

K196E

5/85

(5.8 %)

5/304

(1.6 %)

3.74 (1.06–13.2)

Japanese

Kinoshita et al., 2005 [10]

 c.586A>G

K196E

15/161

(9.3 %)

66/3651

(1.8 %)

5.58 (3.11–10.01)

Japanese

Kimura et al., 2006 [4]

 c.586A>G

K196E

6/60

(10.0 %)

3/234

(1.3 %)

8.56 (2.07–35.30)

Japanese

Ikejiri et al., 2010 [11]

 c.565C>T

R189W

5/116

(4.3 %)

11/1292

(0.9 %)

5.10 (1.70–14.8)

Chinese

Tsay et al., 2004 [26]

 c.565C>T

R189W

59/1003

(5.9 %)

9/1031

(0.9 %)

7.10 (3.50–14.39)

Chinese

Tang et al., 2012 [27]

 c.574_576del

K193del

68/1003

(6.8 %)

25/1031

(2.4 %)

2.93 (1.84–4.67)

Chinese

Tang et al., 2012 [28]

 c.631C>T

R211W

14/500^a

(2.8 %)

6/2953^b

(0.2 %)

n.d.

Korean

Kim et al., 2014 [16]

 c.1218G>A

M406I

9/500^a

(1.8 %)

0/2953^b

(0.0 %)

n.d.

Korean

Kim et al., 2014 [16]

 c.235C>T

R79C

2/500^a

(0.4 %)

7/3046^b

(0.2 %)

n.d.

Korean

Kim et al., 2014 [16]

 c.442T>C

S148P

1/500^a

(0.2 %)

5/3046^b

(0.2 %)

n.d.

Korean

Kim et al., 2014 [16]