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Table 2 Systemic disorders associated with TMA/MAHA (conditions with augmented or enhanced complement activation)

From: Clinical evaluation of thrombotic microangiopathy: identification of patients with suspected atypical hemolytic uremic syndrome

Pregnancy complications

 

Severe hypertension

 

Systemic infections (viremia, fungemia)

 

Systemic malignancies (chemotherapy, tumor cell embolism)

 

Systemic rheumatologic disorders (systemic lupus, scleroderma, catastrophic antiphospholipid syndrome)

 

Hematopoietic stem cell transplantation (myeloablative drugs, immunosuppression, viremia/fungemia)

 

Intravenous radiologic contrast media or exposures to biomaterials during vascular procedures