Table 2 Mean plasma concentrations of coagulation biomarkers at various time points after total knee or total hip arthroplasty
Preoperation | Pretreatment | Day 7a | End of treatment (days 11–14)a | ||||||
|---|---|---|---|---|---|---|---|---|---|
n | Mean (SD) | n | Mean (SD) | n | Mean (SD) | n | Mean (SD) | ||
D-dimer (μg/mL) | Edoxaban | 535 | 0.73 (0.82) | 535 | 9.42 (12.56) | 532 | 4.43b (2.08) | 528 | 5.37b (2.52) |
Enoxaparin | 527 | 0.78 (0.96) | 527 | 10.92 (16.23) | 480 | 5.53 (2.56) | 472 | 6.23 (3.12) | |
F1+2 (pmol/L) | Edoxaban | 535 | 273.9 (150.6) | 535 | 479.7 (741.8) | 532 | 362.8b (164.2) | 528 | 292.1b (167.6) |
Enoxaparin | 527 | 277.8 (160.9) | 527 | 633.2 (3234.9) | 480 | 463.3 (185.6) | 472 | 379.6 (174.4) | |
SFMC (μg/mL) | Edoxaban | 535 | 5.62 (17.86) | 535 | 32.25 (40.47) | 532 | 5.71b (9.76) | 528 | 6.15b (10.72) |
Enoxaparin | 527 | 4.81 (8.42) | 527 | 34.72 (45.62) | 480 | 6.82 (13.99) | 472 | 7.23 (11.78) | |