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Table 2 Baseline profile of hypercoagulability in women eligible for IVF and dynamic changes of the global coagulation tests and molecular biomarkers of hypercoagulability during hormone treatment in the cohort of women eligible for IVF and according to the IVF outcome

From: Impact of blood hypercoagulability on in vitro fertilization outcomes: a prospective longitudinal observational study

  Normal reference range Control
(n = 30)
IVF T0 IVF T1 IVF T2 IVF T3
All women (n = 38) IVF-positive (n = 15) IVF-negative
(n = 23)
All women (n = 38) IVF-positive (n = 15) IVF-negative
(n = 23)
All women (n = 38) IVF-positive (n = 15) IVF-negative
(n = 23)
All women (n = 38) IVF-positive (n = 15) IVF-negative
(n = 23)
Lag time (min) 2.1–3.8 3.41 ± 0.24
UNL: 3.89
LNL: 2.93
2.88 ± 0.59*** 2.94 ± 0.59 2.84 ± 0.59 2.64 ± 0.58°°° 2.60 ± 0.62 2.65 ± 0.58 2.64 ± 0.67өөө 2.68 ± 0.86 2.62 ± 0.56 2.51 ± 0.56+++ 2.87 ± 0.66 2.39 ± 0.53
ttPeak (min) 4.0–6.6 6.48 ± 0.32
UNL: 7.12
LNL: 5.84
5.58 ± 1.06*** 5.68 ± 1.07 5.51 ± 1.07 5.23 ± 0.9°°° 4.97 ± 0.80 5.35 ± 0.93 5.03 ± 0.99 өөө$ 4.95 ± 1.24 5.08 ± 0.85 4.79 ± 1.03+++ 5.54 ± 1.6 4.54 ± 0.81
ETP (nM.min) 1178–1600 1408 ± 80
UNL: 1568
LNL: 1248
1939.65 ± 646*** 1992.10 ± 736.60 1903.89 ± 592.17 1744.52 ± 549.19°°° 2006.95 ± 569.74 1619.55 ± 505.49§ 1950.54 ± 551.03 өөө$ 2172.95 ± 539.59 1819.71 ± 529.65* 1536.38 ± 371.53+ 1931 ± 388.91 1471.5 ± 315.68§
Peak (nM) 222–330 262 ± 25
UNL: 312
LNL: 212
352.3 ± 100*** 359.55 ± 109.08 347.35 ± 95.34 330.32 ± 99.07°°° 399.89 ± 96.32 297.19 ± 83.51§ 372.79 ± 82.11 өөө$L 415.89 ± 73.08 347.44 ± 78.16 * 317.69 ± 80.33+++ 355.69 ± 56 305.02 ± 58.28§
MRI (nM/min) 60–120 86.59 ± 14.10
UNL: 115
LNL: 58
135.27 ± 44*** 135.76 ± 47.86 134.93 ± 42.66 132.62 ± 50.3°°° 173.17 ± 50.21 113.31 ± 38.03§ 159.77 ± 44.53 өөө$L 188.83 ± 48.09 142.67 ± 32.90 * 146.31 ± 49.47+++ 152.66 ± 98 144.2 ± 29.95§
CT (sec) 140–307 245.57 ± 45.61
UNL: 335
LNL: 155
269.53 ± 74.47 251.53 ± 78.8 281.26 ± 70.79 233.78 ± 65.71 206.07 ± 41.44 251.41 ± 72.77§ 236.40 ± 62.41 209.07 ± 42.35 254.62 ± 67.70§ 204.43 ± 23.65+++ 216.8 ± 7.66 197.56 ± 27.03§
CFT (sec) 6–155 80.46 ± 37.26
UNL: 155
LNL: 6
92.82 ± 28.43 93.2 ± 37.25 92.57 ± 21.82 89.94 ± 26.60 88.43 ± 26.73 90.91 ± 27.1 88.14 ± 21.68 86.79 ± 16.79 89.05 ± 24.78 79.79 ± 23.51 64.8 ± 13.08 88.11 ± 24.38§
α angle (°) 55–92 72.86 ± 7.35
UNL: 58
LNL: 88
71.76 ± 5.02 71.60 ± 6.25 71.87 ± 4.18 72.78 ± 4.29 72.86 ± 4.13 72.73 ± 4.48 72.89 ± 3.83 73.57 ± 3.03 72.43 ± 4.28 74.14 ± 4.35 76.8 ± 2.59 72.67 ± 4.53
MCF (mm) 54–74 65.86 ± 4.31
UNL: 75
LNL: 57
64.63 ± 7.59 60.67 ± 10.22 63.91 ± 5.1 64.47 ± 4.48 64.50 ± 4.69 64.45 ± 4.45 64.31 ± 5.02 64.03 ± 5.5 64.29 ± 4.82 66.64 ± 5.39 69 ± 3.81 65.33 ± 5.87
Procoag-PPL (sec) 42–85 60.21 ± 9.3
UNL: 79
LNL: 42
33.0 ± 5.36*** 36.45 ± 5.83 30.53 ± 3.34§ 35.5 ± 7.04°°° 41.37 ± 7.55 32.27 ± 4.18§ 34.14 ± 4.71 өөө 37.45 ± 4.51 32.12 ± 3.63* 39.4 ± 6.45+++ 41.09 ± 5.79 38.32 ± 6.88
TFa (pM) 0.02–0.25 0.24 ± 0.11
UNL: 0,46
LNL: 0,02
0.47 ± 0.31*** 0.32 ± 0.23 0.59 ± 0.31§ 0.40 ± 0.32°° 0.21 ± 0.19 0.51 ± 0.32§ 0.42 ± 0.27 өөө 0.22 ± 0.15 0.55 ± 0.26* 0.4 ± 0.14+++ 0.41 ± 0.18 0.45 ± 0.12
TMa (%) 50–126 90 ± 18
UNL: 126
LNL: 54
127.56 ± 61.54*** 121.60 ± 38.38 131.81 ± 74.50 131 ± 50.54°°° 113.17 ± 54.49 133.86 ± 44.96 119.90 ± 39.26 өөө 103.55 ± 34.07 129.89 ± 39.72§ 126.9 ± 34.27+++ 122.43 ± 7.74 129.82 ± 44.01
FVIII (%) 50–150 105 ± 19
UNL: 143
LNL: 67
101.31 ± 29.22 98.73 ± 27.50 103.14 ± 30.92 117 ± 40.45 115.25 ± 34.90 113.73 ± 28.86 140.10 ± 28.30 өөөL 152.73 ± 24.71 132.39 ± 28.17* 117.7 ± 22.97+LL 133.57 ± 14.08 107.55 ± 22.10§
vWF (%) 50–150 105 ± 21
UNL: 147
LNL: 63
99.44 ± 20.08 95.53 ± 14.31 102.24 ± 23.30 125.17 ± 23.11°°°£ 116.08 ± 18.73 108.23 ± 21.50 129.14 ± 21.37 өөө 137.09 ± 24.77 124.28 ± 18.03 113.4 ± 16.79   
F g (g/l) 1.8–4.0 2.9 ± 0.4
UNL: 3.7
LNL: 2.1
3.18 ± 0.8 3.01 ± 0.7 3.28 ± 0.86 2.98 ± 0.64 3.02 ± 0.9 2.96 ± 0.48 3.02 ± 0.65 3.10 ± 0.9 2.98 ± 0.51 2.9 ± 0.57 3.17 ± 0.64 2.71 ± 0.47
D-Dimers (μg/ml) <0.50 0.25 ± 0.12
UNL: 0,49
LNL: 0.01
0.29 ± 0.12 0.29 ± 0.11 0.31 ± 0.13 0.30 ± 0.09 0.30 ± 0.09 0.3 ± 0.11 0.56 ± 0.28 өөөL 0.39 ± 0.11 0.68 ± 0.31 * 0.7 ± 0.4+++LL 0.49 ± 0.15 0.85 ± 0.45*
  1. UNL upper normal limits, LNL lower normal limits, ETP the endogenous thrombin potential, Peak the peak concentration of thrombin, ttPeak time to reach the peak concentration of thrombin, MRI mean rate index of thrombin generation, CT clotting time, CFT clot formation time, MCF maximum clot firmness, AUC area under curve, α angle reflecting the fibrin polymerization rate, Procoag-PPL procoagulant phospholipid dependent clotting time, FVIII factor VIII, D-Di D-Dimer, TMa thrombomodulin activity, vWF von Willebrand factor, TFa tissue factor activity, Fg fibrinogen
  2. *p < 0.05; **p < 0.01; ***p < 0.001, T0 versus control
  3. °p < 0.05; °° p < 0.01; °°°p < 0.001, T1 versus control
  4. ө p < 0.05; өө p < 0.01; өөө p < 0.001, T2 versus control
  5. + p < 0.05 ; ++ p < 0.01 ; +++ p < 0.001, T3 versus control
  6. £ p < %0.05 T1 versus T0
  7. L p < 0.05 T2 versus T1
  8. LL p < 0.05 T3 versus T2
  9. § p < 0.05; IVF-negative versus IVF-positive