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Table 2 Baseline profile of hypercoagulability in women eligible for IVF and dynamic changes of the global coagulation tests and molecular biomarkers of hypercoagulability during hormone treatment in the cohort of women eligible for IVF and according to the IVF outcome

From: Impact of blood hypercoagulability on in vitro fertilization outcomes: a prospective longitudinal observational study

 

Normal reference range

Control

(n = 30)

IVF T0

IVF T1

IVF T2

IVF T3

All women (n = 38)

IVF-positive (n = 15)

IVF-negative

(n = 23)

All women (n = 38)

IVF-positive (n = 15)

IVF-negative

(n = 23)

All women (n = 38)

IVF-positive (n = 15)

IVF-negative

(n = 23)

All women (n = 38)

IVF-positive (n = 15)

IVF-negative

(n = 23)

Lag time (min)

2.1–3.8

3.41 ± 0.24

UNL: 3.89

LNL: 2.93

2.88 ± 0.59***

2.94 ± 0.59

2.84 ± 0.59

2.64 ± 0.58°°°

2.60 ± 0.62

2.65 ± 0.58

2.64 ± 0.67өөө

2.68 ± 0.86

2.62 ± 0.56

2.51 ± 0.56+++

2.87 ± 0.66

2.39 ± 0.53

ttPeak (min)

4.0–6.6

6.48 ± 0.32

UNL: 7.12

LNL: 5.84

5.58 ± 1.06***

5.68 ± 1.07

5.51 ± 1.07

5.23 ± 0.9°°°

4.97 ± 0.80

5.35 ± 0.93

5.03 ± 0.99 өөө$

4.95 ± 1.24

5.08 ± 0.85

4.79 ± 1.03+++

5.54 ± 1.6

4.54 ± 0.81

ETP (nM.min)

1178–1600

1408 ± 80

UNL: 1568

LNL: 1248

1939.65 ± 646***

1992.10 ± 736.60

1903.89 ± 592.17

1744.52 ± 549.19°°°

2006.95 ± 569.74

1619.55 ± 505.49§

1950.54 ± 551.03 өөө$

2172.95 ± 539.59

1819.71 ± 529.65*

1536.38 ± 371.53+

1931 ± 388.91

1471.5 ± 315.68§

Peak (nM)

222–330

262 ± 25

UNL: 312

LNL: 212

352.3 ± 100***

359.55 ± 109.08

347.35 ± 95.34

330.32 ± 99.07°°°

399.89 ± 96.32

297.19 ± 83.51§

372.79 ± 82.11 өөө$L

415.89 ± 73.08

347.44 ± 78.16 *

317.69 ± 80.33+++

355.69 ± 56

305.02 ± 58.28§

MRI (nM/min)

60–120

86.59 ± 14.10

UNL: 115

LNL: 58

135.27 ± 44***

135.76 ± 47.86

134.93 ± 42.66

132.62 ± 50.3°°°

173.17 ± 50.21

113.31 ± 38.03§

159.77 ± 44.53 өөө$L

188.83 ± 48.09

142.67 ± 32.90 *

146.31 ± 49.47+++

152.66 ± 98

144.2 ± 29.95§

CT (sec)

140–307

245.57 ± 45.61

UNL: 335

LNL: 155

269.53 ± 74.47

251.53 ± 78.8

281.26 ± 70.79

233.78 ± 65.71

206.07 ± 41.44

251.41 ± 72.77§

236.40 ± 62.41

209.07 ± 42.35

254.62 ± 67.70§

204.43 ± 23.65+++

216.8 ± 7.66

197.56 ± 27.03§

CFT (sec)

6–155

80.46 ± 37.26

UNL: 155

LNL: 6

92.82 ± 28.43

93.2 ± 37.25

92.57 ± 21.82

89.94 ± 26.60

88.43 ± 26.73

90.91 ± 27.1

88.14 ± 21.68

86.79 ± 16.79

89.05 ± 24.78

79.79 ± 23.51

64.8 ± 13.08

88.11 ± 24.38§

α angle (°)

55–92

72.86 ± 7.35

UNL: 58

LNL: 88

71.76 ± 5.02

71.60 ± 6.25

71.87 ± 4.18

72.78 ± 4.29

72.86 ± 4.13

72.73 ± 4.48

72.89 ± 3.83

73.57 ± 3.03

72.43 ± 4.28

74.14 ± 4.35

76.8 ± 2.59

72.67 ± 4.53

MCF (mm)

54–74

65.86 ± 4.31

UNL: 75

LNL: 57

64.63 ± 7.59

60.67 ± 10.22

63.91 ± 5.1

64.47 ± 4.48

64.50 ± 4.69

64.45 ± 4.45

64.31 ± 5.02

64.03 ± 5.5

64.29 ± 4.82

66.64 ± 5.39

69 ± 3.81

65.33 ± 5.87

Procoag-PPL (sec)

42–85

60.21 ± 9.3

UNL: 79

LNL: 42

33.0 ± 5.36***

36.45 ± 5.83

30.53 ± 3.34§

35.5 ± 7.04°°°

41.37 ± 7.55

32.27 ± 4.18§

34.14 ± 4.71 өөө

37.45 ± 4.51

32.12 ± 3.63*

39.4 ± 6.45+++

41.09 ± 5.79

38.32 ± 6.88

TFa (pM)

0.02–0.25

0.24 ± 0.11

UNL: 0,46

LNL: 0,02

0.47 ± 0.31***

0.32 ± 0.23

0.59 ± 0.31§

0.40 ± 0.32°°

0.21 ± 0.19

0.51 ± 0.32§

0.42 ± 0.27 өөө

0.22 ± 0.15

0.55 ± 0.26*

0.4 ± 0.14+++

0.41 ± 0.18

0.45 ± 0.12

TMa (%)

50–126

90 ± 18

UNL: 126

LNL: 54

127.56 ± 61.54***

121.60 ± 38.38

131.81 ± 74.50

131 ± 50.54°°°

113.17 ± 54.49

133.86 ± 44.96

119.90 ± 39.26 өөө

103.55 ± 34.07

129.89 ± 39.72§

126.9 ± 34.27+++

122.43 ± 7.74

129.82 ± 44.01

FVIII (%)

50–150

105 ± 19

UNL: 143

LNL: 67

101.31 ± 29.22

98.73 ± 27.50

103.14 ± 30.92

117 ± 40.45

115.25 ± 34.90

113.73 ± 28.86

140.10 ± 28.30 өөөL

152.73 ± 24.71

132.39 ± 28.17*

117.7 ± 22.97+LL

133.57 ± 14.08

107.55 ± 22.10§

vWF (%)

50–150

105 ± 21

UNL: 147

LNL: 63

99.44 ± 20.08

95.53 ± 14.31

102.24 ± 23.30

125.17 ± 23.11°°°£

116.08 ± 18.73

108.23 ± 21.50

129.14 ± 21.37 өөө

137.09 ± 24.77

124.28 ± 18.03

113.4 ± 16.79

  

F g (g/l)

1.8–4.0

2.9 ± 0.4

UNL: 3.7

LNL: 2.1

3.18 ± 0.8

3.01 ± 0.7

3.28 ± 0.86

2.98 ± 0.64

3.02 ± 0.9

2.96 ± 0.48

3.02 ± 0.65

3.10 ± 0.9

2.98 ± 0.51

2.9 ± 0.57

3.17 ± 0.64

2.71 ± 0.47

D-Dimers (ÎĽg/ml)

<0.50

0.25 ± 0.12

UNL: 0,49

LNL: 0.01

0.29 ± 0.12

0.29 ± 0.11

0.31 ± 0.13

0.30 ± 0.09

0.30 ± 0.09

0.3 ± 0.11

0.56 ± 0.28 өөөL

0.39 ± 0.11

0.68 ± 0.31 *

0.7 ± 0.4+++LL

0.49 ± 0.15

0.85 ± 0.45*

  1. UNL upper normal limits, LNL lower normal limits, ETP the endogenous thrombin potential, Peak the peak concentration of thrombin, ttPeak time to reach the peak concentration of thrombin, MRI mean rate index of thrombin generation, CT clotting time, CFT clot formation time, MCF maximum clot firmness, AUC area under curve, α angle reflecting the fibrin polymerization rate, Procoag-PPL procoagulant phospholipid dependent clotting time, FVIII factor VIII, D-Di D-Dimer, TMa thrombomodulin activity, vWF von Willebrand factor, TFa tissue factor activity, Fg fibrinogen
  2. *p < 0.05; **p < 0.01; ***p < 0.001, T0 versus control
  3. °p < 0.05; °° p < 0.01; °°°p < 0.001, T1 versus control
  4. ө p < 0.05; өө p < 0.01; өөө p < 0.001, T2 versus control
  5. + p < 0.05 ; ++ p < 0.01 ; +++ p < 0.001, T3 versus control
  6. £ p < %0.05 T1 versus T0
  7. L p < 0.05 T2 versus T1
  8. LL p < 0.05 T3 versus T2
  9. § p < 0.05; IVF-negative versus IVF-positive
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Thrombosis Journal

ISSN: 1477-9560

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