From: Differential impact of diabetes mellitus on antiplatelet effects of prasugrel and clopidogrel
Prasugrel | Clopidogrel | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
R | ||||||||||
Variable | pre | 0.5 h | 3 h | 6 h | 20 h | pre | 0.5 h | 3 h | 6 h | 20 h |
Age, yrs | −0.28 | −0.16 | −0.33 | −0.31 | −0.27 | 0.14 | −0.32 | −0.18 | −0.30 | −0.13 |
Male | −0.29 | −0.24 | −0.13 | −0.04 | 0.03 | 0.12 | 0.28 | 0.16 | 0.40 | 0.28 |
Body weight, kg | 0.01 | 0.22 | 0.23 | 0.29 | 0.41 | 0.13 | 0.27 | 0.22 | 0.32 | 0.16 |
Body mass index, kg/m2 | −0.02 | 0.23 | 0.25 | 0.27 | 0.38 | 0.26 | 0.19 | 0.13 | 0.26 | 0.08 |
Body surface area, m2 | −0.06 | 0.16 | 0.21 | 0.28 | 0.39 | 0.14 | 0.40 | 0.21 | 0.37 | 0.17 |
Current Smoker | −0.02 | 0.32 | 0.14 | 0.26 | 0.20 | 0.13 | 0.31 | 0.33 | 0.41 | 0.41 |
Alcohol | 0.06 | −0.06 | −0.14 | 0.10 | 0.0 | 0.02 | 0.36 | 0.22 | 0.38 | 0.1 |
Hypertension | 0.38 | 0.20 | 0.28 | 0.38 | 0.30 | 0.46* | 0.30 | 0.16 | 0.01 | 0.09 |
Dyslipidemia | 0.02 | 0.44 | 0.22 | 0.50* | 0.37 | −0.17 | −0.23 | −0.12 | −0.05 | −0.11 |
Diabetes | 0.14 | 0.62** | 0.70*** | 0.64** | 0.68*** | −0.20 | −0.17 | −0.08 | −0.12 | −0.23 |
eGFR, ml/min/1.73m2 | 0.14 | 0.30 | 0.39 | 0.57* | 0.44 | −0.02 | 0.19 | 0.34 | 0.32 | 0.37 |
Platelet counts, ×103/μL | 0.43 | 0.24 | 0.52* | 0.53* | 0.39 | −0.08 | −0.16 | −0.10 | −0.20 | −0.29 |
Proton pump inhibitor | −0.17 | 0.14 | 0.07 | 0.21 | 0.35 | 0.06 | 0.25 | 0.17 | 0.27 | 0.24 |
Concentration (0.5 h) | −0.04 | −0.79*** | −0.75*** | −0.71** | −0.83*** | 0.09 | −0.31 | −0.41 | −0.57* | −0.27 |
ODI3% | 0.15 | −0.16 | 0.18 | 0.05 | 0.03 | 0.12 | 0.50* | 0.48* | 0.49* | 0.44* |