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Table 1 Studies reporting PAI-1 antigen levels (ng/mL) and major adverse cardiovascular events and restenosis

From: Association between plasminogen activator inhibitor-1 and cardiovascular events: a systematic review and meta-analysis

  Event No Event
Reference Year Study Design Follow-up (months) Population of interest N PAI-1 (IU/mL) Range Death MI Restenosis CVA N PAI-1 (IU/mL) Range
Sane et al. [50] 1991 Cohort 24 Fibrinolytics 24 57 58 24 n/a n/a n/a 315 54 53
Cortellaro et al. [51] 1993 Case-Control 24 Subgroups Combined 58 11.3 0.7 13 17 n/a 20 87 7.3 0 5
Brannstrom et al. [52] 1995 Cohort 46 Anticoagulant 38 21.9 15.1 38 n/a n/a n/a 167 16.7 11.8
Juhan-Vague et al. [53] 1996 Cohort 24 MI 106 18.2 8 2 40 66 n/a n/a 2700 14.8 8.9
Nordt et al. [54] 1998 Cohort 12 Fibrinolytics 5 28.8 14.3 n/a n/a 5 n/a 26 27.1 15.4
Alaigh et al. [55] 1998 Cohort 6 Elective PCI 28 20.75 11.06 n/a n/a 28 n/a 45 24.5 13.85
Moss et al. [56] 1999 Cohort 26 MI 81 25 18 25 56 n/a n/a 964 29 28
Redondo et al. [57] 2001 Cohort 24 MI 37 40.725 22.28 2 5 30 n/a 157 42.65 21.02
Fornitz et al. [58] 2001 Cohort 6 Elective PCI 7 82.6 26.6 n/a n/a 7 n/a 12 72.2 27
Bogaty et al. [59] 2001 Case-Control 48 MI 23 23.83 19.04 n/a 8 n/a n/a 77 18.9 16.24
Ganti et al. [60] 2002 Cohort n/a MI 4 80.68 16.38 4 n/a n/a n/a 38 61 21.95
Lip et al. [61] 2002 Cohort 12 Stroke 27 56.5 30.7 27 n/a n/a n/a 59 45.9 23.3
Inoue et al. [62] 2003 Cohort 6 MI 24 28 4 n/a n/a 24 n/a 42 29 4
Christ et al. [20] 2005 Cohort 6 Elective PCI 25 14.8 0.7 n/a n/a 25 n/a 55 16.8 2.1
Robinson et al. [63] 2007 Cohort 5 to 51 Coronary Heart Disease 19 36.3 17.9 2 2 n/a 2 79 45.4 25.6
Katsaros et al. [24] 2008 Cohort 6 to 8 Elective PCI 12 11.69 8.05 n/a n/a 12 n/a 61 22.78 18.76
Thogersen et al. [64] 2009 Case-Control n/a Healthy 50 38.27 16.79 n/a 50 n/a n/a 56 29 15.75
Akkus et al. [65] 2009 Cohort 12 Cardiogenic Shock 33 116.5 97.26 33 n/a n/a n/a 27 71.33 54.79
Pineda et al. [66] 2010 Cohort 36 MI 25 65.13 53.3 4 21 n/a n/a 117 70.1 48.34
Wennberg et al. [67] 2012 Case-Control 168 Healthy 469 57.28 25.83 n/a 469 n/a n/a 895 51.23 25.11
Yano et al. [68] 2013 Cohort 20 Smokers 66 65.73 64.57 n/a 11 n/a 55 744 42.97 36.54
Yano et al. [69] 2014 Cohort 30 Hypertension 42 31.67 16.12 4 13 n/a 16 548 28.33 14.87
Knudsen et al. [70] 2014 Case-Control 12 HIV 54 111 8.5 3 51 n/a n/a 54 92 7
Golukhova et al. [71] 2015 Cohort 28 Elective PCI 23 72.75 29.86 2 9 11 n/a 71 49.75 23.16
  1. CVA cerebrovascular accident