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Table 3 Studies that measure activated protein C

From: Activated protein C plays no major roles in the inhibition of coagulation or increased fibrinolysis in acute coagulopathy of trauma-shock: a systematic review

Reference (year) Diagnosis Control Normal control Activated protein C
Methods
Thrombin
Surrogate markers
PAI-1
[35] (2011) APTT and/or PTINR above normal reference Non-ACOTS No Yes
ELISA
Yes
PF1 + 2, TAT
Yes
[36] (2012) PTINR> 1.3 No No Yes
Enzyme capture assay (banzamidine)
No No
[37] (2012) No Low histone No Yes
Enzyme capture assay (banzamidine)
No No
[38] (2013) APTT and/or PTINR above normal reference NA No Yes
ELISA
Yes
PF1 + 2, TAT
Yes
[39] (2013) PT INR 1.3, APTT> 35 s. Non-coagulopathic No Yes
Not shown
No No
[40] (2016) PT ratio > 1.2 Normal control
Non-ACOTS
Healthy volunteer Yes
ELISA
No No
[41] (2017) Amplitude of clot at 5 min by ROTEM Non-ATC No Yes
Enzyme capture assay (benzamidine)
Yes
PF1 + 2
Yes
[42] (2013) PT ratio > 1.2 Normal control
Non-ACOTS
Healthy volunteer Yes
Prothrombinase activity
Yes
Soluble fibrin
No