Table 3 Studies that measure activated protein C
Reference (year) | Diagnosis | Control | Normal control | Activated protein C Methods | Thrombin Surrogate markers | PAI-1 |
|---|---|---|---|---|---|---|
[35] (2011) | APTT and/or PTINR above normal reference | Non-ACOTS | No | Yes ELISA | Yes PF1 + 2, TAT | Yes |
[36] (2012) | PTINR> 1.3 | No | No | Yes Enzyme capture assay (banzamidine) | No | No |
[37] (2012) | No | Low histone | No | Yes Enzyme capture assay (banzamidine) | No | No |
[38] (2013) | APTT and/or PTINR above normal reference | NA | No | Yes ELISA | Yes PF1 + 2, TAT | Yes |
[39] (2013) | PT INR 1.3, APTT> 35 s. | Non-coagulopathic | No | Yes Not shown | No | No |
[40] (2016) | PT ratio > 1.2 | Normal control Non-ACOTS | Healthy volunteer | Yes ELISA | No | No |
[41] (2017) | Amplitude of clot at 5 min by ROTEM | Non-ATC | No | Yes Enzyme capture assay (benzamidine) | Yes PF1 + 2 | Yes |
[42] (2013) | PT ratio > 1.2 | Normal control Non-ACOTS | Healthy volunteer | Yes Prothrombinase activity | Yes Soluble fibrin | No |