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Table 1 Diagnostic criteria for infectious DIC

From: Differences and similarities between disseminated intravascular coagulation and thrombotic microangiopathy

  ISTH P JSTH P JMHLW P JAAM P
PLT (× 103/μl) 100  > 50 1 120  > 80 1 120  > 80 1 120  > 8.0 1
50  2 80  > 50 2 80  > 50 2   
   50  3 50  3 80  3
Reduction of PLT    30% 1*    30% 1*
     50% 3*
Prothrombin time ratio or Prolongation (s) 3  < 6.0 1 1.25  < 1.67 1 1.25  < 1.67 1 1.2  1
6  2 1.67  2 1.67  2   
Fibrinogen (g/L) 1.0  1   1.5  > 1.0 1  
   1.0  2
Fibrin related markers, FDP (μg/ml)    10  < 20 1 10  < 20 1 10  < 25 1
Increase 2 20  < 40 2 20  < 40 2   
Markedly increase 3 40  3 40  3 25  3
Antithrombin    <  70% 1  
TAT or SF    2 fold higher of NR   
Underlying diseases      Positive 1  
Bleeding    Positive 1
OF due to thrombosis    Positive 1
SIRS       Positive 1
DIC   5    5    7    4 
  1. ISTH International Society of Thrombosis and Haemostasis, JSTH Japanese Society of Thrombosis and Hemostasis, JMHLW Japanese Ministry of Health, Labor and Welfare, JAAM Japanese Association for Acute Medicine, PLT platelet count, FDP fibrinogen and fibrin degradation products, TAT thrombin antithrombin complex, SF soluble fibrin, SIRS systemic inflammatory response syndrome, DIC disseminated intravascular coagulation
  2. *PLT and reduction of PLT pointes should be within 3 points