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Table 1 Diagnostic criteria for infectious DIC

From: Differences and similarities between disseminated intravascular coagulation and thrombotic microangiopathy

 

ISTH

P

JSTH

P

JMHLW

P

JAAM

P

PLT (× 103/μl)

100 ≧ > 50

1

120 ≧ > 80

1

120 ≧ > 80

1

120 ≧ > 8.0

1

50 ≧

2

80 ≧ > 50

2

80 ≧ > 50

2

  
  

50 ≧

3

50 ≧

3

80 ≧

3

Reduction of PLT

  

30%

1*

  

30%

1*

    

50%

3*

Prothrombin time ratio or Prolongation (s)

3 ≦ < 6.0

1

1.25 ≦ < 1.67

1

1.25 ≦ < 1.67

1

1.2 ≦

1

6 ≦

2

1.67 ≦

2

1.67 ≦

2

  

Fibrinogen (g/L)

1.0 ≧

1

 

1.5 ≧ > 1.0

1

 
  

1.0 ≧

2

Fibrin related markers, FDP (μg/ml)

  

10 ≦ < 20

1

10 ≦ < 20

1

10 ≦ < 25

1

Increase

2

20 ≦ < 40

2

20 ≦ < 40

2

  

Markedly increase

3

40 ≦

3

40 ≦

3

25 ≦

3

Antithrombin

  

<  70%

1

 

TAT or SF

  

2 fold higher of NR

  

Underlying diseases

    

Positive

1

 

Bleeding

  

Positive

1

OF due to thrombosis

  

Positive

1

SIRS

     

Positive

1

DIC

 

5 ≦

 

5 ≦

 

7 ≦

 

4 ≦

  1. ISTH International Society of Thrombosis and Haemostasis, JSTH Japanese Society of Thrombosis and Hemostasis, JMHLW Japanese Ministry of Health, Labor and Welfare, JAAM Japanese Association for Acute Medicine, PLT platelet count, FDP fibrinogen and fibrin degradation products, TAT thrombin antithrombin complex, SF soluble fibrin, SIRS systemic inflammatory response syndrome, DIC disseminated intravascular coagulation
  2. *PLT and reduction of PLT pointes should be within 3 points