Table 3 Differences and similarities between TMA and DIC
| Â | Â | Severe DIC | Severe TMA |
|---|---|---|---|
Symptoms | Organ failure | Often (Lung, Kidney, Shock) | Usually (Kidney, CNS) |
Bleeding and bleeding tendency | Frequent | Frequent | |
Blood pressure | Low | High | |
Hematuria | Sometimes | Frequent | |
Anemia | Often | Usually | |
Laboratory data | Platelet count | Low | Low |
Hemoglobin | Often low | Low | |
Fibrin related markers | Markedly high | Slightly high | |
Prothrombin time | Often prolong | Normal | |
Antithrombin | Often low | Normal | |
Albumin | Often low | Normal | |
Creatinine | Often high | High | |
Total bilirubin, LDH | Often high | High | |
Treatments | Supportive therapy | Recommended | Recommended |
Blood transfusion (RBC, FFP) | Recommended | Recommended, | |
Blood transfusion (PC) | Recommended | Not recommended | |
Anticoagulant | Recommended (Japan) | Not mentioned | |
PE/FFP | Not mentioned | Recommended | |
Special treatment | AT, rhTM (Japan) | Hemodialysis (HUS), Eculizumab (aHUS), Rituximab (TTP) |