Fig. 3

Plasma APC levels are not increased in septic patients during a 30–60-min period of rTM treatment, while TAT levels are decreased during the treatment period. a Blood samples were collected from eight patients with sepsis-associated DIC before and after administration of rTM (130 U/kg: red symbols; 380 U/kg: blue symbols) on day 1 and day 2. Plasma sTM levels were determined by ELISA. b Plasma TAT levels were analyzed by STACIA CLEIA TAT. c Plasma APC levels were analyzed by the OLIGOBIND APC activity assay. d Plasma protein C levels were measured by a synthetic chromogenic substrate method using HemosIL Protein C. A paired t-test was used for comparisons before and after rTM treatment. *P < 0.05, **P < 0.01