Table 3 Measurement of rivaroxaban plasma concentrations
No | Delay (h) | PT (sec) | Biophen® DiXaI (ng/ml) | Estimated cc at trough (ng/ml) | Clearance (L/h) | Potential PK drug interactions | Potential PD drug interactions |
|---|---|---|---|---|---|---|---|
1 | 28 | 18.7 | 84.8 | 98 | 3.3 | – | Ibuprofen |
2 | 22 | 19.6 | 237.5 | 181 a | 2.0 | Diltiazem (↑), Clarithromycin (↑) | Escitalopram |
3 | 38 | 15.4 | 70.8 | 125 a | 2.9 | Simvastatin (↑) | / |
4 | 27 | 17.7 | 58.3 | 69 | 3.9 | – | Diclofenac, Escitalopram |
5 | 27 | N/K | 139.4 | 134 a | 2.4 | Amiodarone (↑) | Aspirin |
6 | 26 | 12.9 | 4.9 | 12 | 7.9 | Amiodarone (↑) | / |
7 | 37 | 14.4 | 18.3 | 44 | 4.8 | Diltiazem (↑) | / |
8 | 27 | 15.3 | 86.5 | 89 | 3.0 | / | / |
9 | 9 | 26.0 | 357.8 | 251 a | 3.2 | / | / |
10 | 13 | N/K | 184.7 | 72 | 3.9 | / | Duloxetine, Paroxetine |