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Table 2 Recommended regimens for treatment with standard anticoagulation in children [2]

From: Rivaroxaban versus standard anticoagulation for acute venous thromboembolism in childhood. Design of the EINSTEIN-Jr phase III study

Anticoagulant drug Age or body weight Initial dosage Target
Warfarin    INR 2.0–3.0
Acenocoumarol    INR 2.0–3.0
Phenprocoumon    INR 2.0–3.0
Unfractionated heparin    aPTT times 1.5–2.5
Enoxaparin <  2 months 1.5 mg/kg bid  
> 2 months 1 mg/kg bid  
Tinzaparin <  2 months 275 U/kg od  
2–12 months 250 U/kg od  
1–5 years 240 U/kg od  
5–10 years 200 U/kg od  
> 10 years 175 U/kg od  
Dalteparin   129 ± 43 U/kg od  
Reviparin <  5 kg 150 U/kg bid  
>  5 kg 100 U/kg bid  
Fondaparinux   0.1 mg/kg od  
  1. aPPT activated partial thromboplastin time; bid twice-daily; INR international normalized ratio; od once-daily; U unit