Rivaroxaban versus standard anticoagulation for acute venous thromboembolism in childhood. Design of the EINSTEIN-Jr phase III study

Table 2 Recommended regimens for treatment with standard anticoagulation in children [2]

Anticoagulant drug	Age or body weight	Initial dosage	Target
Warfarin			INR 2.0–3.0
Acenocoumarol			INR 2.0–3.0
Phenprocoumon			INR 2.0–3.0
Unfractionated heparin			aPTT times 1.5–2.5
Enoxaparin	< 2 months	1.5 mg/kg bid
Enoxaparin	> 2 months	1 mg/kg bid
Tinzaparin	< 2 months	275 U/kg od
	2–12 months	250 U/kg od
	1–5 years	240 U/kg od
	5–10 years	200 U/kg od
	> 10 years	175 U/kg od
Dalteparin		129 ± 43 U/kg od
Reviparin	< 5 kg	150 U/kg bid
Reviparin	> 5 kg	100 U/kg bid
Fondaparinux		0.1 mg/kg od

aPPT activated partial thromboplastin time; bid twice-daily; INR international normalized ratio; od once-daily; U unit

ISSN: 1477-9560