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Table 1 TTP-like patient demographics, laboratory test results and treatment

From: Thrombotic thrombocytopenic purpura (TTP)-like syndrome in the HIV era

  Age Sex Hb WCC Plts RDW Fragments INR PTT D-dimers DATT LDH Haptoglobin Urea Creatinine HIV-infected HIV VL CD4+ T cell count ARV therapy Days of PE
Units Yrs   g/dL ×109/L ×109/L %    s mg/L    g/L mmol/L ug/L   copies/mL Cells/ul   
Reference range    11,6 16,4 3,9 12,60 186–454 12,4 17,3 Absent   31–48 < 0.25 Negative 100–190 0,4-2,4 2.1–7.1 49–90    332–1642   
1 48 M 8.8 (11.5) 10.4 33 (276) 33.8 3+ 1.02 ND 1.48 ND 2365 (300) < 0.1 9.9 126 Yes LTDL 141 Yes 20
2 37 F 10.5 (12.4) 12.85 18 (351) 19.6 2+ 1.81 32.6 ND Neg 1073 (320) < 0.1 12.4 105 Yes LTDL 346 Yes 20
3 39 M 7.1 (12.9) 5.42 12 (268) 24.5 2+ 1.09 32.6 ND Neg 698 (468) < 0.1 4 88 Yes 321,158 194 Yes 10
4 47 F 7.2 (12.8) 7.84 8 (219) 23.3 3+ 1.14 30.8 3.20 ND 2023 (311) < 0.1 9 128 Yes 191,000 134 No 25
5 32 F 4.6 (11.5) 8.56 8 (272) 30.5 3+ 1.12 32.9 1.16 ND 941 (191) < 0.1 1.8 57 Yes 373,000 80 No 11
6 27 F 8 (14.1) 4.92 35 (244) 32.6 3+ 1.01 ND 11.90 Negative 2102 (180) < 0.1 4.7 52 Yes 8642 182 Yes 10
7 43 F 10.2 (12.8) 8.4 16 (86) 24.6 3+ 1.01 30.0 0.75 IgG + 2005 (160) < 0.1 9.1 79 No N/A N/A N/A 12
8 30 F 7.3 (9.7) 6.56 15 (175) 33.9 3+ 1.15 ND 11.90 Negative 1836 (178) ND 4.8 60 Yes 42 113 Yes 10
9 35 F 5.5 (11.1) 9.17 5 (280) 26.6 3+ 1.2 31.0 6.49 Negative 1768 (182) < 0.1 3.8 71 Yes ND 585 Yes 18
10 45 F 6.7 (10.4) 4.16 18 (105) 22.7 3+ 1.06 44.3 ND IgG + 950 (227) < 0.1 4.1 67 Yes 228,912 54 No 20
11 43 F 7.8 (9.5) 10.4 18 (23) 23.9 1+ 1.62 43.1 0.56 IgG + 1441 ND 17 211 No N/A N/A N/A 12b
12 44 F 6.3 (14.3) 13.91 3 (290) 27.9 3+ 1.21 43.1 10.00 ND 2708 (478) < 0.1 7.8 113 Yes 2150 187 Yes 18
13 43 F 6.1 (10.4) 10.5 10 (274) 25 3+ 1.17 36.9 7.13 ND 1357 [32] < 0.1 5.5 94 Yes 72,905 264 No 12
14 40 M 7.4 (10.8) 4.15 21 (254) 20.6 2+ 1.11 41.1 1.0 IgG + 1068 (273) < 0.1 7.7 101 Yes 26,065 215 No 14
15 34 F 6.5 (10.7) 8.96 6 (270) 19 2+ 1.35 33.8 17.00 Negative 1683 (257) < 0.1 6.4 96 No N/A N/A N/A 12
16 56 F 5.8 (8.5) 14.7 5 (328) 34.2 3+ 1.3 33.5 ND Negative 3339 (305) < 0.1 6.6 80 Yes LTDL 180 Yes 11
17 34 F 6.7 (12.5) 13.67 5 (248) 27.2 3+ 1.28 31.7 0.00 IgG + 2404 (206) < 0.1 6.5 110 Yes 562,635 421 No 11
18 44 M 7.5 19.35 25 20.2 3+ 1.14 34.0 ND ND 5472 ND 27.3 262 Unknown ND ND Unknown 1a
19 33 F 6.5 (10.2) 8.9 6 (203) 19 2+ 1.35 33.8 17.00 Negative 1683 (195) < 0.1 6.4 96 No N/A NA N/A 12
20 38 F 7.9 (9.5) 5.6 3 (253) 15.2 2+ 1.05 43.6 1.93 IgG + 827 (244) < 0.1 5.3 67 Yes 2,030,000 100 No 15
21 35 M 2.7 (7) 13.2 29 (134) 13.5 1+ 2.38 92.3 0.97 IgG+ 978 (476) < 0.1 5.6 136 Yes 1,010,000 34 No 15
Median 39   7.1 (10.95) 9.065 12 (253.5) 24.5   1.14 33.6 2.565   1683 (244)   6.6 96   209,956 181   12
IQR (25–75%) 34–44   6,35-7725 6,56-13,2   20,2 27,725 6–20,3 1.08–1.2 32–43 0.99–10.5   1069-2299   1.2–3 73–122.7   21,709-420,409 110–227   11–18
  1. aPatient demised on day 1. b Patient defaulted after 12 days of plasma exchange. Values in brackets denote discharge haemoglobin, platelet and LDH levels
  2. Abbreviations: Yrs years, Hb haemoglobin, WCC White cell count, RDW red cell distribution width, Plts platelets, LDH lactate dehydrogenase, ARV antiretroviral therapy, VL viral load, LTDL viral load lower than detectable limit
  3. PE:plasma exchange, N/A not applicable