Skip to main content

Table 2 Assessment of coagulation markers and bleeding scores with consanguinity/ethnicity

From: Correction to: Identification of novel mutations in congenital afibrinogenemia patients and molecular modeling of missense mutations in Pakistani population

IP#

Fibrinogen Level

(g/l)

Thrombin Time

(Sec)

Prothrombin Time

(Sec)

Activated partial thromboplastin Time (aPTT) (Sec)

Bleeding Score

Consanguinity

Interfamilial Relation

Ethnic Origin

*C1

0.01

23

> 120

> 180

20

positive

Unrelated

NA

C2

0.02

24

> 120

> 180

21

positive

Unrelated

Punjabi

C3

0

33

> 120

> 180

22

positive

Unrelated

Punjabi

C4

0.1

24

> 120

> 180

17

positive

Unrelated

Urdu Speaking

C5

0.02

31

> 120

> 180

20

positive

Unrelated

Sindhi

C6

0.01

25

> 120

> 180

20

positive

Unrelated

Urdu speaking

C7

0.02

29

> 120

> 180

22

positive

Unrelated

Sindhi

C8

0.0

30

> 120

> 180

20

positive

Unrelated

Sindhi

C9

0.0

32

> 120

> 180

22

positive

Unrelated

Punjabi

C10

0.01

25

> 120

> 180

16

positive

Unrelated

Punjabi

C11A

0.02

28

> 120

> 180

18

positive

**

Punjabi

C11B

0.01

24

> 120

> 180

16

positive

Punjabi

C12

0.0

30

> 120

> 180

21

positive

Unrelated

Punjabi

C13A

0.02

24

> 120

> 180

20

positive

**

Punjabi

C13B

0.01

25

> 120

> 180

21

positive

Punjabi

  1. Shows the individual test values of PT, aPTT and fibrinogen (Clauss Method), consanguinity and the relationship status. Bleeding score calculated, Tosetto et al [26]. ** Siblings, NA = not available, s (seconds). The fibrinogen levels in all patients were found to be equal to or lower than 0 .1g/l (Normal Range 2-4 g/dl), PT more than 120 s (Normal Range 9–11 s) aPTT more than 180 s (Normal Range 24–27 s) and prolonged thrombin time (normal range 10–13 s). Ethnicity explains the frequency of majorly affected, thickly populated and largest province of Pakistan (Punjab).