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Table 1 Properties of the different P2Y12 inhibitors. Adapted and modified from [2, 3]

From: A brief review on resistance to P2Y12 receptor antagonism in coronary artery disease

  Clopidogrel Prasugrel Ticagrelor
Chemical class Thienopyridine Thienopyridine Cyclopentyl-triazolopyrimidine
Administration Oral Oral Oral
Dose 300–600 mg orally then 75 mg a day 60 mg orally then 10 mg a day 180 mg orally then 90 mg twice a day
Binding reversibility Irreversible Irreversible Reversible
Binding site ADP-binding site ADP-binding site Allosteric binding site
Activation Prodrug, with variable liver metabolism Prodrug, with predictable liver metabolism Active drug, with additional active metabolite
Onset of loading dose effect 2–6 h 30 min 30 min
Duration of effect 3–10 days 7–10 days 3–5 days
Plasma half-life of active P2Y12 inhibitor 30–60 min 30–60 min 6–12 h
Inhibition of adenosine reuptake No No Yes