Sepsis and septic shock: endothelial molecular pathogenesis associated with vascular microthrombotic disease

Thrombosis Journal

Table 1 Examples of thrombocytopenia (TCIP) in sepsis-associated coagulopathy (VMTD)

	Specific pathogens	Commonly involved organs	Associated clinical syndromes
Bacteria	Neisseria meningitides	adrenals; meninges	Waterhouse-Friderichsen syndrome
	E. coli O157:H7	bowels; kidneys; brain	GE; HUS; MODS
	MRSA	lung; multiorgans	ARDS
	Klebsiella pneumonia	lungs; multiorgans	ARDS; TAMOF
	Various bacterial sepsis	multiorgans	ARDS; TAMOF
Viruses	Ebola	lungs; liver; multiorgans	ARDS; hepatic necrosis
	H1N1 influenza	brain; lungs; multiorgans	Encephalopathy; ARDS
	MERS-CoV	lungs	ARDS
	SARS-CoV	lungs	ARDS
	Hantavirus	heart; lungs; kidneys	HCPS; HPS; HFRS
	Dengue	adrenals; multiorgans	DSS
	SFTS virus	multiorgans	SFTS
	Hepatitis A virus	liver	Fulminant hepatic failure
Fungi	Candida albicans	multiorgans	ARDS
Rickettsia	Rickettsia rickettsii	skin; multiorgans	RMSF
Parasites	Plasmodium falciparum	brain; multiorgans	Cerebral malaria; ARDS
Parasites	Plasmodium vivax	lungs; multiorgans	ARDS

Abbreviations: ARDS acute respiratory distress syndrome, DSS dengue shock syndrome, GE gastroenteritis, HUS hemolytic uremic syndrome, MERS-CoV Middle East respiratory syndrome-corona virus, MODS multiorgan dysfunction syndrome, MRSA methicillin resistant Staphylococcus aureus, SARS-CoV severe acute respiratory syndrome-corona virus, SFTS severe fever with thrombocytopenia syndrome, TAMOF thrombocytopenia and multiple organ failure, HCPS hantavirus cardiopulmonary syndrome, HPS hantavirus pulmonary syndrome, HFRS hemorrhagic fever with renal syndrome, DSS dengue shock syndrome, RMSF Rocky mountain spotted fever

ISSN: 1477-9560