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Table 1 Examples of thrombocytopenia (TCIP) in sepsis-associated coagulopathy (VMTD)

From: Sepsis and septic shock: endothelial molecular pathogenesis associated with vascular microthrombotic disease

  Specific pathogens Commonly involved organs Associated clinical syndromes
Bacteria Neisseria meningitides adrenals; meninges Waterhouse-Friderichsen syndrome
E. coli O157:H7 bowels; kidneys; brain GE; HUS; MODS
MRSA lung; multiorgans ARDS
Klebsiella pneumonia lungs; multiorgans ARDS; TAMOF
Various bacterial sepsis multiorgans
Viruses Ebola lungs; liver; multiorgans ARDS; hepatic necrosis
H1N1 influenza brain; lungs; multiorgans Encephalopathy; ARDS
MERS-CoV lungs ARDS
SARS-CoV lungs ARDS
Hantavirus heart; lungs; kidneys HCPS; HPS; HFRS
Dengue adrenals; multiorgans DSS
SFTS virus multiorgans SFTS
Hepatitis A virus liver Fulminant hepatic failure
Fungi Candida albicans multiorgans ARDS
Rickettsia Rickettsia rickettsii skin; multiorgans RMSF
Parasites Plasmodium falciparum brain; multiorgans Cerebral malaria; ARDS
Plasmodium vivax lungs; multiorgans ARDS
  1. Abbreviations: ARDS acute respiratory distress syndrome, DSS dengue shock syndrome, GE gastroenteritis, HUS hemolytic uremic syndrome, MERS-CoV Middle East respiratory syndrome-corona virus, MODS multiorgan dysfunction syndrome, MRSA methicillin resistant Staphylococcus aureus, SARS-CoV severe acute respiratory syndrome-corona virus, SFTS severe fever with thrombocytopenia syndrome, TAMOF thrombocytopenia and multiple organ failure, HCPS hantavirus cardiopulmonary syndrome, HPS hantavirus pulmonary syndrome, HFRS hemorrhagic fever with renal syndrome, DSS dengue shock syndrome, RMSF Rocky mountain spotted fever