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Table 1 Non-DIC, Pre-DIC, DIC without hypofibrinogenemia and DIC with hypofibrinogenemia

From: Usefulness of the APTT waveform for the diagnosis of DIC and prediction of the outcome or bleeding risk

  Non-DIC Pre-DIC DIC without hypofibrinogenemia DIC with hypofibrinogenemia
Number 121 25 35 30
Age (years) 61 (37–75) 71 (67–80)* 71 (58–76) 63 (54–70)+
Sex (F:M) 60: 61 8: 17 13: 22 13: 17
Platelet counts (104/μl) 15.8 (9.7–26.7) 7.5 (5.0–11.4)*** 4.8 (3.3–6.7)***, ## 4.4 (2.7–5.9)***, ###
PT-ratio 1.1 (1.0–1.2) 1.3 (1.1–1.5)** 1.3 (1.1–1.5)***, 1.4 (1.3–1.7)***, #,+
FDP (μg/ml) 13.6 (7.5–29.5) 28.4 (15.0–40.7) ** 44.4 (23.2–71.8)*** 29.9 (13.8–57.8)***
Fibrinogen (mg/dl) 443 (320–598) 365 (293–449)* 345 (219–404)**, 143 (103–169)***, ###, +++
DIC score 3.0 (2.0–4.0) 6.0 (6.0–6.0)*** 7.0 (7.0–8.0)***, ### 8.0 (7.0–9.0)***, ###
  1. DIC disseminated intravascular coagulation, PT prothrombin time, FDP fibrinogen and fibrin degradation products
  2. *, P < 0.05; **, P < 0.01; ***, P < 0.001 compared with non-DIC
  3. #, P < 0.05; ##, P < 0.01; ###, P < 0.001 compared with pre-DIC
  4. +, P < 0.05; +++, P < 0.001 compared with DIC without hypofibrinogen