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Table 1 Non-DIC, Pre-DIC, DIC without hypofibrinogenemia and DIC with hypofibrinogenemia

From: Usefulness of the APTT waveform for the diagnosis of DIC and prediction of the outcome or bleeding risk

 

Non-DIC

Pre-DIC

DIC without hypofibrinogenemia

DIC with hypofibrinogenemia

Number

121

25

35

30

Age (years)

61 (37–75)

71 (67–80)*

71 (58–76)

63 (54–70)+

Sex (F:M)

60: 61

8: 17

13: 22

13: 17

Platelet counts (104/μl)

15.8 (9.7–26.7)

7.5 (5.0–11.4)***

4.8 (3.3–6.7)***, ##

4.4 (2.7–5.9)***, ###

PT-ratio

1.1 (1.0–1.2)

1.3 (1.1–1.5)**

1.3 (1.1–1.5)***,

1.4 (1.3–1.7)***, #,+

FDP (μg/ml)

13.6 (7.5–29.5)

28.4 (15.0–40.7) **

44.4 (23.2–71.8)***

29.9 (13.8–57.8)***

Fibrinogen (mg/dl)

443 (320–598)

365 (293–449)*

345 (219–404)**,

143 (103–169)***, ###, +++

DIC score

3.0 (2.0–4.0)

6.0 (6.0–6.0)***

7.0 (7.0–8.0)***, ###

8.0 (7.0–9.0)***, ###

  1. DIC disseminated intravascular coagulation, PT prothrombin time, FDP fibrinogen and fibrin degradation products
  2. *, P < 0.05; **, P < 0.01; ***, P < 0.001 compared with non-DIC
  3. #, P < 0.05; ##, P < 0.01; ###, P < 0.001 compared with pre-DIC
  4. +, P < 0.05; +++, P < 0.001 compared with DIC without hypofibrinogen