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Table 2 Parameters of APTT waveform in patients with and without DIC and healthy volunteers

From: Usefulness of the APTT waveform for the diagnosis of DIC and prediction of the outcome or bleeding risk

   HV Without DIC Pre-DIC DIC Without HF With HF
2ndDP Time (seconds) 35.5*** (32.6–37.4) 43.9 (36.6–52.7) 54.6* (41.0–71.3) 63.7*** (47.4–84.9) 58.8*** (46.2–73.9) 72.5*** (49.7–110)
Height (mabs) 457** (411–535) 648 (379–973)) 460* (191–772) 151*** (83.2–326) 286*** (144–427) 107*** (26.5–148)
NH (mabs) 234** (170–255) 316 (164–499) 176** (93.2–308) 66.4*** (39.4–150) 134*** (61.6–188) 55.0*** (14.5–64.5)
Width (sec) 7.45*** (6.80–8.00) 12.9 (11.2–16.8) 17.7** (12.5–24.3) 15.1* (12.4–20.5) 15.1* (12.4–20.5) 21.4*** (12.7–38.2)
1stDP Time (sec) 38.7*** (36.3–40.8) 50.2 (41.2–58.6) 60.5* (45.8–76.4) 70.7*** (52.1–96.8) 64.9*** (52.2–81.0) 78.6*** (51.8–128.2)
Height (mabs) 183*** (144–200)) 389 (241–544) 251** (154–358) 103*** (64.2–208) 200*** (116–257) 61.2*** (36.8–93.9)
Width (sec) 19.5*** (18.0–20.3) 65,2 (54.8–72.1) 65.2 (54.0–195) 66.5 (56.0–200) 64.6 (57.6–200) 75.1 (55.0–200)
1/2FFP Time (sec) 40.9*** (37.8–42.7) 52.5 (43.1–61.5) 61.6* (47.1–78.9) 75.0*** (54.8–99.3) 69.1*** (54.8–87.9) 80.9*** (54.7–142)
Height (mabs) 242*** (207–305) 462 (338–586) 328* (271–490) 265*** (178–371) 319*** (240–399) 195*** (170–286)
  1. 2ndDP, second derivative peak; 1stDP, first derivative peak, 1/2FFP, fibrin formation peak; NH, negative height; DIC, disseminated intravascular coagulation; HF, hypofibrinogenemia
  2. Data was shown as median (25–75%tile)
  3. ***, p < 0.001, **, p < 0.01 or: *p < 0.05 compared with patients without DIC