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Table 2 Parameters of APTT waveform in patients with and without DIC and healthy volunteers

From: Usefulness of the APTT waveform for the diagnosis of DIC and prediction of the outcome or bleeding risk

  

HV

Without DIC

Pre-DIC

DIC

Without HF

With HF

2ndDP

Time (seconds)

35.5***

(32.6–37.4)

43.9

(36.6–52.7)

54.6*

(41.0–71.3)

63.7***

(47.4–84.9)

58.8***

(46.2–73.9)

72.5***

(49.7–110)

Height (mabs)

457**

(411–535)

648

(379–973))

460*

(191–772)

151***

(83.2–326)

286***

(144–427)

107***

(26.5–148)

NH (mabs)

234**

(170–255)

316

(164–499)

176**

(93.2–308)

66.4***

(39.4–150)

134***

(61.6–188)

55.0***

(14.5–64.5)

Width (sec)

7.45***

(6.80–8.00)

12.9

(11.2–16.8)

17.7**

(12.5–24.3)

15.1*

(12.4–20.5)

15.1*

(12.4–20.5)

21.4***

(12.7–38.2)

1stDP

Time (sec)

38.7***

(36.3–40.8)

50.2

(41.2–58.6)

60.5*

(45.8–76.4)

70.7***

(52.1–96.8)

64.9***

(52.2–81.0)

78.6***

(51.8–128.2)

Height (mabs)

183***

(144–200))

389

(241–544)

251**

(154–358)

103***

(64.2–208)

200***

(116–257)

61.2***

(36.8–93.9)

Width (sec)

19.5***

(18.0–20.3)

65,2

(54.8–72.1)

65.2

(54.0–195)

66.5

(56.0–200)

64.6

(57.6–200)

75.1

(55.0–200)

1/2FFP

Time (sec)

40.9***

(37.8–42.7)

52.5

(43.1–61.5)

61.6*

(47.1–78.9)

75.0***

(54.8–99.3)

69.1***

(54.8–87.9)

80.9***

(54.7–142)

Height (mabs)

242***

(207–305)

462

(338–586)

328*

(271–490)

265***

(178–371)

319***

(240–399)

195***

(170–286)

  1. 2ndDP, second derivative peak; 1stDP, first derivative peak, 1/2FFP, fibrin formation peak; NH, negative height; DIC, disseminated intravascular coagulation; HF, hypofibrinogenemia
  2. Data was shown as median (25–75%tile)
  3. ***, p < 0.001, **, p < 0.01 or: *p < 0.05 compared with patients without DIC