Factor V Leiden 1691G > A mutation and the risk of recurrent pregnancy loss (RPL): systematic review and meta-analysis

Eslami, Mohammad Masoud; khalili, Majid; Soufizomorrod, Mina; Abroun, Saeid; Razi, Bahman

doi:10.1186/s12959-020-00224-z

Table 1 Characteristics of studies included in meta-analysis

From: Factor V Leiden 1691G > A mutation and the risk of recurrent pregnancy loss (RPL): systematic review and meta-analysis

Study author	Year	Country	Study design	Ethnicity	Total cases/controls	Age case/control (Mean)	Genotyping method	Quality score
Souza et al. [34]	1999	Brazil	case-control	South America	56/384	29.6 / 24.3	RLFP-PCR	7
Brenner et al. [35]	1999	Israel	case-control	Asia	76/106	31 ± 5 / 31 ± 6	RLFP-PCR	6
Wramsby et al. [36]	2000	Sweden	case-control	Europe	62/69	21–39 / 21–39	RLFP-PCR	7
Murphy et al. [37]	2000	Ireland	case-control	Europe	41/540	32 ± 0.74 / NR	RLFP-PCR	6
Pihusch et al. [33]	2000	Germany	case-control	Europe	102/128	35 / 32	RLFP-PCR	6
Younis et al.	2000	Israel	case-control	Asia	78/139	30.0 ± 4.4 / 30.7 ± 4.2	RLFP-PCR	6
Foka et al. [14]	2000	Greece	case-control	Europe	80/100	33 / 35	RLFP-PCR	6
Rai et al.	2001	London	cohort	Europe	1111/150	33.5 / 33	RLFP-PCR	8
Carp et al.	2002	Israel	case-control	Asia	108/82	31 / 36	RLFP-PCR	6
Finan et al. [38]	2002	Lebanon	case-control	Asia	110/67	32.3 ± 5.3 / 33.9 ± 7.3	RLFP-PCR	6
Hohlagschwandtner et al.	2003	Australia	case-control	Oceania	145/101	32 / 56	Multiplex PCR	7
Pauer et al. [39]	2003	German	case-control	Europe	30/122	31.3 / NR	RLFP-PCR	6
Mtiraoui et al	2004	Tunisia	case-control	Africa	146/99	29.0 ± 6.1 / 28.9 ± 5.3	RLFP-PCR	6
Aksoy et al.	2005	Turkey	case-control	Europe	41/50	32 ± 5.54 / 29 ± 4.66	PCR	5
Mahjoub et al. [40]	2005	Tunisia	case-control	Africa	200/200	28.68 ± 5.61 / 28.24 ± 5.51	RLFP-PCR	8
Ulukus et al.	2006	Turkey	case-control	Europe	10/53	29.1 ± 5.2 / 28.0 ± 4.8	PCR	5
Sotiriadis et al.	2006	Greece	case-control	Europe	99/102	32.2 / 32.2	RLFP-PCR	6
Mohammad et al. [21]	2007	Syrian	case-control	Asia	35/45	29.6 ± 6.3 / 28.8 ± 6.8	Q-PCR	5
Altintas et al. [41]	2007	Turkey	case-control	Europe	114/185	30.6 ± 4.4 / 30.5 ± 4.3	Q-PCR	7
Toth et al. [42]	2008	Germany	case-control	Europe	151/157	33.2 ± 4.6 / 45.2 ± 12.6	RLFP-PCR	7
Pasquier et al	2008	France	case-control	Europe	311/599	32.8 / 34.3	Q-PCR	8
Biswas et al. [43]	2008	India	case-control	Asia	85/31	27.9 ± 0.3 / 26 ± 0.5	RLFP-PCR	6
Lvanov et al.	2009	Bulgaria	case-control	Europe	153/100	29.7 / 31.0	RLFP-PCR	7
Mukhopadhyay et al. [44]	2009	India	case-control	Asia	84/80	24.9 ± 3.3 / 24.9 ± 3.3	RLFP-PCR	6
Ciacci et al. [45]	2009	Italy	case-control	Europe	39/72	36.24 ± 8.26 / 30.10 ± 8.60	Multiplex PCR	6
Mohamed et al. [46]	2010	Egypt	case-control	Africa	20/20	29.0 ± 4.80 / 31.4 ± 6.82	PCR	5
Hussein et al. [47]	2010	Palestine	case-control	Asia	145/205	31.9 / 32	ARMS-PCR	7
Serrano et al. [17]	2011	Portugal	case-control	Europe	100/100	32 ± 4.25 / 30.9 ± 5.19	PCR	7
Settin et al.	2011	Egypt	case-control	Africa	72/70	19 to 38 / 19 to 38	PCR	6
Dissanayake et al. [32]	2012	Sri Lanka	case-control	Asia	200/200	32.1 ± 5.6 / 32.4 ± 4.6	RLFP-PCR	8
Gazi et al.	2012	Turkey	case-control	Europe	57/47	30.12 ± 7.32 / 27.80 ± 6.36	PCR	6
Karata et al.	2012	Turkey	case-control	Europe	84/84	31.6 ± 3.7 / 32.2 ± 3.9	Q-PCR	6
Mierla et al. [48]	2012	Romania	case-control	Europe	283/100	33.76 / 32.8	RLFP-PCR	7
Ozdemir et al. [49]	2012	Turkey	case-control	Europe	543/106	27.8 ± 2.1 / 28.9 ± 2.2	Q-PCR	7
Torabi et al. [50]	2012	Iran	case-control	Asia	100/100	NR / NR	RLFP-PCR	6
Kaur et al.	2012	India	case-control	Asia	107/588	24.89 / 25.32	RLFP-PCR	7
Parveen et al.	2012	India	case-control	Asia	1000/500	28.4 ± 5.9 / 31.9 ± 7.3	ARMS-PCR	8
Ardestani et al.	2012	Iran	case-control	Asia	80/80	28.8 / 23.6	RLFP-PCR	6
Cardona et al. [51]	2012	Colombia	case-control	South America	93/206	34.1 ± 0.9 / 41.6 ± 0.7	RLFP-PCR	7
Kazerooni et al. [52]	2013	Iran	case-control	Asia	60/ 60	24.8 ± 3.9 / 24.6 ± 4.7	PCR	5
Baumann et al.	2013	Germany	cohort	Europe	641/157	32.95 ± 4.94 / 33.16 ± 6.24	RLFP-PCR	8
Parand et al. [53]	2013	Iran	case-control	Asia	90/44	29.21 ± 5.9 / 28.75 ± 5.2	RLFP-PCR	6
Zonouzi et al. [54]	2013	Iran	case-control	Asia	89/50	30.18 ± 4.95 / 31.54 ± 4.81	ARMS-PCR	6
Dutra et al.	2013	Brazil	case-control	South America	145/135	31.72 / 29.86	Q-PCR	6
Isaoglu et al.	2013	Turkey	case-control	Europe	60/40	29.14 ± 6.18 / 30.50 ± 6.77	NR	6
Pietropolli et al. [55]	2014	Italy	case-control	Europe	186/129	35.2 ± 5.1 / 40.4 ± 5.3	Rapid-cycle PCR	7
Lino et al.	2014	Brazil	case-control	South America	83/98	30.3 / 40.2	Q-PCR	6
Sharma et al. [56]	2015	India	case-control	Asia	78/78	28.6 ± 3.32 / 30.5 ± 2.57	RLFP-PCR	6
Farahmand et al.	2015	Iran	case-control	Asia	330/350	30.37 / 29.88	PCR	8
Kashif et al. [57]	2015	Pakistan	case-control	Asia	56/56	28.55 ± 4.69 / 28.61 ± 4.38	PCR	6
Gonçalves et al. [58]	2016	Brazil	case-control	South America	137/100	32.1 / 25.8	RLFP-PCR	7
Khaniani et al. [59]	2016	Iran	case-control	Asia	210/160	less than 40 / NR	RLFP-PCR	7
Eldeen et al.	2017	Arabia	case-control	Asia	96/96	37.7 ± 4.6 / 36.5 ± 5.8	PCR	6
Wolski et al. [60]	2017	Poland	case-control	Europe	359/400	30.99 ± 4.50 / 30.05 ± 3.81	RLFP-PCR	8
Elgari et al. [61]	2017	Arabia	case-control	Asia	60/80	38 ± 12 / 38 ± 12	Multiplex PCR	6
Mahmutbegović et al. [62]	2017	Bosnia	case-control	Europe	51/154	32.9 ± 5.1 / 31.7 ± 6.6	Q-PCR	6
Wingeyer et al.	2017	Argentina	case-control	South America	247/107	32 / NR	Q-PCR	7
Jusić et al.	2018	Bosnia	case-control	Europe	60/80	33.05 / 34.08	RLFP-PCR	6
Taghi Kardi et al.	2018	Iran	case-control	Asia	250/116	29.7 ± 3.4 / 30.4 ± 3.2	Multiplex PCR	7
Xu et al.	2018	China	case-control	Asia	426/444	29.26 ± 4.294 / 34.50 ± 4.895	Multiplex PCR	8
Bigdeli et al. [63]	2018	Iran	case-control	Asia	200/200	23.0 ± 3.8 / 25.1 ± 4.4	RLFP-PCR	8
Reddy et al. [64]	2019	India	case-control	Asia	50/28	26.8 / 27.6	RLFP-PCR	5
Yengel et al.	2019	turkey	case-control	Europe	145/105	30.5 ± 6.5 /30.5 ± 6.7	real-time PCR	6

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