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Table 2 Distribution of genotype and allele among RPL patients and controls

From: Factor V Leiden 1691G > A mutation and the risk of recurrent pregnancy loss (RPL): systematic review and meta-analysis

Study author RPL cases Healthy control P-HWE MAF
GG GA AA G A GG GA AA G A
Souza et al. [34] 52 4 0 108 4 378 6 0 762 6 0/87 0/007
Brenner et al. [35] 52 19 5 123 29 95 11 0 201 11 0/57 0/051
Wramsby et al. [36] 51 10 1 112 12 67 2 0 136 2 0/9 0/014
Murphy et al. [52] 39 2 0 80 2 527 13 0 1067 13 0/77 0/012
Pihusch et al. [33] 94 8 0 196 8 117 11 0 245 11 0/61 0/042
Younis et al. 63 12 3 138 18 131 8 0 270 8 0/72 0/028
Foka et al. [14] 65 15 0 145 15 96 4 0 196 4 0/83 0/02
Rai et al. 1037 72 2 2146 76 138 12 0 288 12 0/6 0/04
Carp et al. 104 4 0 212 4 77 5 0 159 5 0/77 0/03
Finan et al. [38] 65 38 7 168 52 56 11 0 123 11 0/46 0/082
Hohlagschwandtner et al. 130 15 0 275 15 97 4 0 198 4 0/83 0/019
Pauer et al. [39] 28 2 0 58 2 113 9 0 235 9 0/67 0/036
Mtiraoui et al. 116 24 6 256 36 93 6 0 192 6 0/75 0/03
Aksoy et al. 31 9 1 71 11 45 5 0 95 5 0/7 0/05
Mahjoub et al. [40] 152 40 8 344 56 189 11 0 389 11 0/68 0/027
Ulukus et al. 7 3 0 17 3 49 3 1 101 5 ≤0.001 0/047
Sotiriadis et al. 94 5 0 193 5 99 3 0 201 3 0/88 0/014
Mohammad et al. [21] 25 10 0 60 10 41 4 0 86 4 0/75 0/044
Altintas et al. [41] 105 9 0 219 9 172 13 0 357 13 0/62 0/035
Toth et al. [42] 138 13 0 289 13 145 12 0 302 12 0/61 0/038
Pasquier et al. 296 15 0 607 15 574 25 0 1173 25 0/6 0/02
Biswas et al. [43] 83 2 0 168 2 31 0 0 62 0 ≤0.001 0
Lvanov et al. 133 19 1 285 21 93 7 0 193 7 0/71 0/035
Mukhopadhyay et al. [44] 80 4 0 164 4 80 0 0 160 0 ≤0.001 0
Ciacci et al. [45] 38 1 0 77 1 70 2 0 142 2 0/9 0/013
Mohamed et al. [46] 6 12 2 24 16 19 1 0 39 1 0/9 0/025
Hussein et al. [47] 104 36 5 244 46 181 24 0 386 24 0/37 0/058
Serrano et al. [17] 95 5 0 195 5 95 5 0 195 5 0/79 0/025
Settin et al. 54 17 1 125 19 69 1 0 139 1 0/95 0/007
Dissanayake et al. [32] 196 4 0 396 4 195 5 0 395 5 0/85 0/012
Gazi et al. 50 6 1 106 8 43 4 0 90 4 0/76 0/042
Karata et al. 66 16 2 148 20 66 18 0 150 18 0/27 0/107
Mierla et al. [48] 260 21 2 541 25 95 5 0 195 5 0/79 0/025
Ozdemir et al. [49] 433 109 1 975 111 104 2 0 210 2 0/92 0/009
Torabi et al. [50] 87 12 1 186 14 96 4 0 196 4 0/83 0/02
Kaur et al. 102 4 1 208 6 573 15 0 1161 15 0/75 0/012
Parveen et al. 950 50 0 1950 50 488 12 0 988 12 0/78 0/012
Ardestani et al. 78 2 0 158 2 79 1 0 159 1 0/95 0/006
Cardona et al. [51] 92 1 0 185 1 205 1 0 411 1 0/97 0/002
Kazerooni et al. [52] 43 12 5 98 22 54 4 2 112 8 0.48 0.734
Baumann et al. 592 49 0 1233 49 145 12 0 302 12 0/61 0/038
Parand et al. [53] 72 15 3 159 21 38 6 0 82 6 0/62 0/068
Zonouzi et al. [54] 87 2 0 176 2 50 0 0 100 0 ≤0.001 0
Dutra et al. 142 3 0 287 3 131 4 0 266 4 0/86 0/014
Isaoglu et al. 47 13 0 107 13 39 1 0 79 1 0/93 0/012
Pietropolli et al. [55] 168 18 0 354 18 125 4 0 254 4 0/85 0/015
Lino et al. 79 4 0 162 4 96 2 0 194 2 0/91 0/01
Sharma et al. [56] 36 40 2 112 44 77 1 0 155 1 0/95 0/006
Farahmand et al. 302 28 0 632 28 340 10 0 690 10 0/78 0/014
Kashif et al. [57] 53 3 0 109 3 56 0 0 112 0 ≤0.001 0
Gonçalves et al. [58] 133 4 0 270 4 98 2 0 198 2 0/91 0/01
Khaniani et al. [59] 202 8 0 412 8 158 2 0 318 2 0/93 0/006
Eldeen et al. 0 72 24 72 120 0 94 2 94 98 ≤0.001 0/51
Wolski et al. [60] 333 26 0 692 26 378 21 1 777 23 0/23 0/028
Elgari et al. [61] 56 4 0 116 4 74 6 0 154 6 0/72 0/037
Mahmutbegović et al. [62] 44 7 0 95 7 142 12 0 296 12 0/61 0/038
Wingeyer et al. 239 8 0 486 8 105 2 0 212 2 0/92 0/009
Jusić et al. 51 9 0 111 9 77 3 0 157 3 0/86 0/018
Taghi Kardi et al. 236 12 2 484 16 109 5 2 223 9 ≤0.001 0/038
Xu et al. 426 0 0 852 0 443 1 0 887 1 0/98 0/001
Bigdeli et al. [63] 150 30 20 330 70 192 8 0 392 8 0/77 0/02
Yengel et al. 130 1 14 261 29 102 0 3 204 6 0/65 0/394
  1. P-HWE p-value for Hardy–Weinberg equilibrium; MAF Minor allele frequency of control group
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