Epistaxis
|
Regular
|
PERI
|
|
1% soaked pledgets or sprayed
|
[16,17,18]
|
Menorrhagia
|
Regular or bleeding disorder
|
PERI
|
|
2-4 g/d (max. 5 d)
|
[19]
|
Trauma
|
Regular
|
PRE
|
|
1 g (over 10 min)
|
[20]
|
PERI
|
|
1 g (over 8 h)
|
Postpartum hemorrhage
|
Regular
|
PRE
|
|
1 g (over 10 min)
|
[21]
|
POST
|
|
1 g if bleeding continuous after 30 min or if bleeding restarts after 24 h
|
Myomectomy and hysterectomy
|
Regular (A)
|
PRE
|
|
10-15 mg/kg
|
[22,23,24,25,26]
|
PERI (optional)
|
|
1 mg/kg/h (continuous)
|
[23, 24]
|
Regular (B)
|
PERI
|
|
2 g soaked gauzes
|
[24, 26]
|
Orthopedic
|
Regular
|
PRE
|
|
10-15 mg/kg (max 1.2 g, over 30 min)
|
[27, 28]
|
PERI (optional)
|
|
1-3 g diluted in 30-100 mL NS (topical with closure)
|
[27,28,29,30]
|
POST
|
|
10-15 mg/kg (after 3 hours or via infusion), optionally repeated
|
[27, 28, 31,32,33,34,35]
|
Cardiac surgery
|
Low bleeding risk
|
PRE
|
|
10-15 mg/kg
|
[36]
|
PERI
|
|
1 mg/kg/h continuous infusion (6-8 hours)
|
High bleeding risk
|
PRE
|
|
30 mg/kg
|
PERI
|
|
16 mg/kg/h continuous infusion (6-8 hours)
|
Maxillofacial surgery
|
Regular (A)
|
PRE
|
|
10-20 mg/kg
|
[37,38,39]
|
Regular (B)
|
PERI
|
|
1% irrigation
|
Minor oral surgery
|
Anticoagulant or bleeding disorders
|
PERI (optional)
|
|
5% irrigation
|
[40, 41]
|
POST
|
|
10 mL 5% mouthwash (4x/d for 2-7 d)
|
[40,41,42,43]
|
Bleeding disorders (A)
|
POST
|
|
15-25 mg/kg or 1-1.5 g 2-3x/d
|
[42, 43]
|
Bleeding disorders (B)
|
PRE
|
|
10 mg/kg
|
POST (optional)
|
|
10 mg/kg 3-4x/d
|
(Adeno) tonsillectomy
|
Regular (A)
|
PRIOR
|
|
10 mg/kg
|
[44, 45]
|
POST (optional)
|
|
250 mg 3x/d for 1d and 500 mg 1x/d for 2 d
|
Regular (B)
|
POST
|
|
4% irrigation
|
Rhinoplasty
|
Regular (A)
|
PRE
|
|
10 mg/kg
|
[46]
|
Regular (B)
|
PRE
|
|
1 g
|
POST (optional)
|
|
1g 3x/d (up to 5 d)
|
Liver transplantation and resection
|
Regular
|
PERI
|
|
10-40 mg/kg/h
|
[47, 48]
|
Prostate surgery
|
Regular (A)
|
PERI
|
|
2 g 3x/d
|
[49, 50]
|
POST
|
|
2 g 3x/d (first postoperative day)
|
Regular (B)
|
PERI
|
|
1 g diluted in 200 mL NS or 10 mg/kg for 0.5 h
|
Regular (C)
|
PRE
|
|
500 mg injection
|
PERI
|
|
250 mg/h
|
Regular (D)
|
PRE
|
|
500 mg injection
|
POST
|
|
500 mg injection
|
Regular (E)
|
PERI
|
|
500 mg irrigation
|
Nephrolithotomy
|
Regular (A)
|
PRE
|
|
1 g
|
[51, 52]
|
POST
|
|
500 mg 3x/d for 1 d
|
Regular (B)
|
PERI
|
|
0.1% irrigation
|
Melasma
|
Regular (A)
|
PERI
|
|
40-500 mg/d 2 x/d (for 12 weeks)
|
[53,54,55]
|
Regular (B)
|
PERI
|
|
10% topical or with microneedling 2 x/d (for 12 weeks)
|
Mohs micrographic surgery
|
Regular
|
PERI
|
|
100-600 mg subcutaneous
|
[56]
|
Burn wounds or skin grafting
|
Regular
|
PRE
|
|
15 mg/kg
|