Indication for TXA | Patient | Recommended TXA dose | References | ||
---|---|---|---|---|---|
Menorrhagia | Minor RI | PERI | 1.3 g 2x/d (max. 5 d) | ||
Mild RI | PERI | 1.3 g/d (max. 5 d) | |||
Severe RI | PERI | 0.65 g/d (max. 5 d) | |||
Orthopedic | Minor RI | PRE | 10-15 mg/kg (max 1.2 g, over 30 min) | [151] | |
PERI | 11.25 mg/kg (8h and 16h after first dose) | ||||
Mild RI | PRE | 10-15 mg/kg (max 1.2 g, over 30 min) | |||
PERI | 8.4 mg/kg (8h and 16h after first dose) | ||||
Severe RI | PRE | 10-15 mg/kg (max 1.2 g, over 30 min) | |||
PERI | 6.3 mg/kg (8h and 16h after first dose) | ||||
Cardiac surgery | Low bleeding risk + minor RI | PRE | 10-15 mg/kg | ||
PERI | 3.75 mg/kg/h continuous infusion | ||||
Low bleeding risk + mild RI | PRE | 10-15 mg/kg | |||
PERI | 2.50 mg/kg/h continuous infusion | ||||
Low bleeding risk + severe RI | PRE | 10-15 mg/kg | |||
PERI | 1.25 mg/kg/h continuous infusion | ||||
High bleeding risk + minor RI | PRE | 25-30 mg/kg | |||
PERI | 11-16 mg/kg/h continuous infusion | ||||
High bleeding risk + mild RI | PRE | 25-30 mg/kg | |||
PERI | 5-10 mg/kg/h continuous infusion | ||||
High bleeding risk + severe RI | PRE | 25-30 mg/kg | |||
PERI | 3-5 mg/kg/h continuous infusion | ||||
Minor oral surgery | Minor RI | POST | 10 mg/kg 2x/d | ||
Mild RI | POST | 10 mg/kg 1x/d | |||
Severe RI | POST | 10 mg/kg 1x/2d or 5 mg/kg 1x/d |