Table 2 TXA dose adaptations for patients with renal insufficiency for various indications
| Indication for TXA | Patient | Recommended TXA dose | References | ||
|---|---|---|---|---|---|
| Menorrhagia | Minor RI | PERI |
| 1.3 g 2x/d (max. 5 d) | [150, 151] |
| Mild RI | PERI |
| 1.3 g/d (max. 5 d) | ||
| Severe RI | PERI |
| 0.65 g/d (max. 5 d) | ||
| Orthopedic | Minor RI | PRE |
| 10-15 mg/kg (max 1.2 g, over 30 min) | [151] |
| PERI |
| 11.25 mg/kg (8h and 16h after first dose) | |||
| Mild RI | PRE |
| 10-15 mg/kg (max 1.2 g, over 30 min) | ||
| PERI |
| 8.4 mg/kg (8h and 16h after first dose) | |||
| Severe RI | PRE |
| 10-15 mg/kg (max 1.2 g, over 30 min) | ||
| PERI |
| 6.3 mg/kg (8h and 16h after first dose) | |||
| Cardiac surgery | Low bleeding risk + minor RI | PRE |
| 10-15 mg/kg | [151, 152] |
| PERI |
| 3.75 mg/kg/h continuous infusion | |||
| Low bleeding risk + mild RI | PRE |
| 10-15 mg/kg | ||
| PERI |
| 2.50 mg/kg/h continuous infusion | |||
| Low bleeding risk + severe RI | PRE |
| 10-15 mg/kg | ||
| PERI |
| 1.25 mg/kg/h continuous infusion | |||
| High bleeding risk + minor RI | PRE |
| 25-30 mg/kg | ||
| PERI |
| 11-16 mg/kg/h continuous infusion | |||
| High bleeding risk + mild RI | PRE |
| 25-30 mg/kg | ||
| PERI |
| 5-10 mg/kg/h continuous infusion | |||
| High bleeding risk + severe RI | PRE |
| 25-30 mg/kg | ||
| PERI |
| 3-5 mg/kg/h continuous infusion | |||
| Minor oral surgery | Minor RI | POST |
| 10 mg/kg 2x/d | [150, 151] |
| Mild RI | POST |
| 10 mg/kg 1x/d | ||
| Severe RI | POST |
| 10 mg/kg 1x/2d or 5 mg/kg 1x/d | ||
- with d day(s), min minutes, h hours, pre preoperative dose, peri perioperative dose, post postoperative dose, NS normal saline, RI renal insufficiency with minor RI when GFR = 60-89 mL/min/1.73m2; mild RI when GFR = 30-59 mL/min/1.73m2; severe RI when GFR < 29 mL/min/1.73m2 and GFR = glomerular filtration ratio.
= oral dose, 
= intravenous dose
= oral dose, 
= intravenous dose