Menorrhagia
|
Minor RI
|
PERI
|
|
1.3 g 2x/d (max. 5 d)
|
[150, 151]
|
Mild RI
|
PERI
|
|
1.3 g/d (max. 5 d)
|
Severe RI
|
PERI
|
|
0.65 g/d (max. 5 d)
|
Orthopedic
|
Minor RI
|
PRE
|
|
10-15 mg/kg (max 1.2 g, over 30 min)
|
[151]
|
PERI
|
|
11.25 mg/kg (8h and 16h after first dose)
|
Mild RI
|
PRE
|
|
10-15 mg/kg (max 1.2 g, over 30 min)
|
PERI
|
|
8.4 mg/kg (8h and 16h after first dose)
|
Severe RI
|
PRE
|
|
10-15 mg/kg (max 1.2 g, over 30 min)
|
PERI
|
|
6.3 mg/kg (8h and 16h after first dose)
|
Cardiac surgery
|
Low bleeding risk + minor RI
|
PRE
|
|
10-15 mg/kg
|
[151, 152]
|
PERI
|
|
3.75 mg/kg/h continuous infusion
|
Low bleeding risk + mild RI
|
PRE
|
|
10-15 mg/kg
|
PERI
|
|
2.50 mg/kg/h continuous infusion
|
Low bleeding risk + severe RI
|
PRE
|
|
10-15 mg/kg
|
PERI
|
|
1.25 mg/kg/h continuous infusion
|
High bleeding risk + minor RI
|
PRE
|
|
25-30 mg/kg
|
PERI
|
|
11-16 mg/kg/h continuous infusion
|
High bleeding risk + mild RI
|
PRE
|
|
25-30 mg/kg
|
PERI
|
|
5-10 mg/kg/h continuous infusion
|
High bleeding risk + severe RI
|
PRE
|
|
25-30 mg/kg
|
PERI
|
|
3-5 mg/kg/h continuous infusion
|
Minor oral surgery
|
Minor RI
|
POST
|
|
10 mg/kg 2x/d
|
[150, 151]
|
Mild RI
|
POST
|
|
10 mg/kg 1x/d
|
Severe RI
|
POST
|
|
10 mg/kg 1x/2d or 5 mg/kg 1x/d
|