Table 4 Association of rSS with MACE in enrolled patients according to subgroup of characteristics by OCT
Variables | MACE /Total | Crude model | Adjusted model I | Adjust model II | Adjust model III | ||||
|---|---|---|---|---|---|---|---|---|---|
crude HR(95%CI) | crude P value | Adj I. HR(95%CI) | Adj. P value | adj. HR(95%CI) | Adj. P value | adj. HR(95%CI) | Adj. P value | ||
TCFA = 0 | |||||||||
rSSlow | 7 (12.10) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) |
rSSmid | 13 (13.10) | 1.03 (0.41,2.59) | 0.944 | 0.98 (0.39,2.46) | 0.963 | 1.04 (0.38,2.86) | 0.942 | 1.32 (0.45,3.88) | 0.613 |
rSShigh | 11 (22.90) | 1.99 (0.77,5.15) | 0.153 | 1.96 (0.76,5.07) | 0.164 | 2.86 (0.99,8.27) | 0.053 | 5.85 (1.78,19.28) | 0.004* |
Trend test | 31 (15.1) | 1.46 (0.88,2.42) | 0.139 | 1.46 (0.88,2.43) | 0.145 | 1.79 (1,3.21) | 0.049 | 2.52 (1.32,4.81) | 0.005* |
TCFA = 1 | |||||||||
rSSlow | 1 (7.10) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) |
rSSmid | 9 (25.70) | 4.28 (0.54,33.82) | 0.168 | 4.20 (0.53,33.58) | 0.176 | 6.97 (0.78,62.52) | 0.083 | 11.14 (0.44,279.13) | 0.142 |
rSShigh | 7 (35.00) | 5.51 (0.68,44.83) | 0.110 | 5.94 (0.72,48.76) | 0.097 | 3.94 (0.45,34.81) | 0.217 | 2.3 (0.13,40.85) | 0.570 |
Trend test | 17 (24.6) | 1.81 (0.89,3.68) | 0.100 | 1.96 (0.93,4.14) | 0.078 | 1.41 (0.68,2.9) | 0.356 | 1.04 (0.34,3.18) | 0.947 |
Plaque erosion | |||||||||
rSSlow | 5 (12.50) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) |
rSSmid | 6 (10.90) | 0.83 (0.25,2.71) | 0.752 | 0.71 (0.21,2.43) | 0.591 | 0.95 (0.25,3.69) | 0.945 | 1.86 (0.29,11.92) | 0.512 |
rSShigh | 4 (16.70) | 1.4 (0.38,5.22) | 0.615 | 1.16 (0.3,4.51) | 0.834 | 2.92 (0.6,14.18) | 0.184 | 14.57 (1.22,173.3) | 0.034* |
Trend test | 15 (12.60) | 1.16 (0.57,2.36) | 0.681 | 1.06 (0.51,2.22) | 0.879 | 1.7 (0.71,4.05) | 0.234 | 3.63 (1.03,12.86) | 0.045* |
Plaque rupture | |||||||||
rSSlow | 3 (9.40) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) |
rSSmid | 16 (20.30) | 2.26 (0.66,7.77) | 0.194 | 2.15 (0.63,7.41) | 0.223 | 1.69 (0.47,6.07) | 0.421 | 1.36 (0.34,5.44) | 0.663 |
rSShigh | 14 (31.80) | 3.8 (1.09,13.23) | 0.036* | 3.81 (1.09,13.38) | 0.037* | 3.06 (0.82,11.34) | 0.095 | 2.65 (0.62,11.22) | 0.186 |
Trend test | 33 (21.30) | 1.84 (1.10,3.10) | 0.021* | 1.88 (1.11,3.20) | 0.020* | 1.77 (0.98,3.2) | 0.059 | 1.73 (0.88,3.4) | 0.111 |
Without Macrophage | |||||||||
rSSlow | 5 (14.7) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) |
rSSmid | 10 (15.4) | 0.98 (0.33,2.87) | 0.971 | 0.94 (0.32,2.8) | 0.912 | 0.78 (0.22,2.8) | 0.708 | 0.67 (0.17,2.62) | 0.568 |
rSShigh | 6 (23.1) | 1.53 (0.47,5.02) | 0.483 | 1.55 (0.47,5.1) | 0.471 | 1.74 (0.43,7.03) | 0.435 | 1.84 (0.36,9.43) | 0.462 |
Trend test | 21 (16.8) | 1.25 (0.67,2.35) | 0.485 | 1.26 (0.67,2.39) | 0.470 | 1.36 (0.62,2.96) | 0.443 | 1.3 (0.52,3.25) | 0.577 |
With Macrophage | |||||||||
rSSlow | 3 (7.9) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) |
rSSmid | 12 (17.4) | 2.31 (0.65,8.20) | 0.194 | 2.4 (0.67,8.64) | 0.179 | 3.37 (0.83,13.61) | 0.088 | 4.99 (1.05,23.72) | 0.043* |
rSShigh | 12 (28.6) | 4.12 (1.16,14.62) | 0.028* | 4.26 (1.2,15.13) | 0.025* | 4.76 (1.19,18.97) | 0.027* | 6.6 (1.24,35.02) | 0.027* |
Trend test | 27 (18.1) | 1.95 (1.12,3.38) | 0.017* | 1.97 (1.13,3.42) | 0.016* | 1.96 (1.08,3.56) | 0.027* | 2.39 (1.11,5.13) | 0.026* |
Without Calcification | |||||||||
rSSlow | 6 (13.6) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) |
rSSmid | 9 (14.1) | 0.99 (0.35,2.78) | 0.982 | 0.86 (0.3,2.45) | 0.776 | 0.95 (0.3,2.96) | 0.93 | 1.13 (0.34,3.74) | 0.847 |
rSShigh | 9 (34.6) | 2.87 (1.02,8.05) | 0.046* | 2.77 (0.98,7.81) | 0.054 | 2.72 (0.76,9.8) | 0.126 | 2.41 (0.6,9.67) | 0.214 |
Trend test | 24 (17.9) | 1.79 (1,3.18) | 0.049* | 1.79 (0.99,3.23) | 0.055 | 1.72 (0.84,3.49) | 0.135 | 1.55 (0.75,3.2) | 0.235 |
With Calcification | |||||||||
rSSlow | 2 (7.1) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) |
rSSmid | 13 (18.6) | 2.72 (0.61,12.07) | 0.189 | 2.83 (0.63,12.65) | 0.172 | 3.68 (0.75,18.01) | 0.107 | 6.88 (1.02,46.59) | 0.048* |
rSShigh | 9 (21.4) | 3.15 (0.68,14.59) | 0.142 | 3.31 (0.71,15.37) | 0.127 | 5.06 (1,25.61) | 0.05 | 23.25 (2.81,192.71) | 0.004* |
Trend test | 24 (17.1) | 1.53 (0.84,2.76) | 0.162 | 1.55 (0.86,2.81) | 0.144 | 1.92 (1.01,3.67) | 0.048 | 4.18 (1.72,10.16) | 0.002* |
Without Micro-calcification | |||||||||
rSSlow | 6 (13.6) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) |
rSSmid | 9 (13.4) | 0.93 (0.33,2.62) | 0.895 | 0.79 (0.28,2.26) | 0.663 | 0.85 (0.27,2.65) | 0.779 | 0.92 (0.28,3) | 0.894 |
rSShigh | 10 (37) | 3.03 (1.1,8.35) | 0.032 | 2.81 (1.01,7.8) | 0.047* | 2.67 (0.75,9.43) | 0.128 | 2.44 (0.62,9.62) | 0.201 |
Trend test | 25 (18.1) | 1.89 (1.06,3.35) | 0.03 | 1.87 (1.03,3.37) | 0.038* | 1.74 (0.86,3.52) | 0.126 | 1.56 (0.75,3.26) | 0.234 |
With Micro-calcification | |||||||||
rSSlow | 2 (7.1) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) |
rSSmid | 13 (19.4) | 2.94 (0.66,13.07) | 0.156 | 3.09 (0.69,13.78) | 0.140 | 3.92 (0.81,19.08) | 0.09 | 6.82 (1.06,44) | 0.044 |
rSShigh | 8 (19.5) | 2.93 (0.62,13.8) | 0.174 | 3.14 (0.66,14.86) | 0.150 | 4.39 (0.85,22.76) | 0.078 | 16.84 (2.03,139.54) | 0.009* |
Trend test | 23 (16.9) | 1.44 (0.8,2.6) | 0.229 | 1.48 (0.82,2.68) | 0.193 | 1.76 (0.91,3.37) | 0.091 | 3.46 (1.41,8.48) | 0.007* |
Without lipid plaque | |||||||||
rSSlow | 5 (11.6) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) |
rSSmid | 10 (16.4) | 1.35 (0.46,3.94) | 0.586 | 1.32 (0.45,3.88) | 0.613 | 1.71 (0.51,5.65) | 0.383 | 3.16 (0.71,14.08) | 0.132 |
rSShigh | 6 (20.7) | 1.8 (0.55,5.91) | 0.331 | 1.72 (0.52,5.69) | 0.373 | 3.7 (0.97,14.09) | 0.055 | 10.48 (1.68,65.48) | 0.012* |
Trend test | 21 (15.8) | 1.34 (0.74,2.43) | 0.330 | 1.31 (0.72,2.38) | 0.372 | 1.93 (0.98,3.83) | 0.059 | 3.24 (1.29,8.11) | 0.012* |
With lipid plaque | |||||||||
rSSlow | 3 (10.3) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) |
rSSmid | 12 (16.4) | 1.67 (0.47,5.93) | 0.426 | 1.6 (0.45,5.7) | 0.465 | 1.27 (0.33,4.82) | 0.728 | 1.25 (0.29,5.34) | 0.767 |
rSShigh | 12 (30.8) | 3.39 (0.96,12.02) | 0.059 | 3.45 (0.97,12.25) | 0.056 | 2.64 (0.69,10.13) | 0.158 | 2.33 (0.48,11.26) | 0.291 |
Trend test | 27 (19.1) | 1.9 (1.07,3.4) | 0.029* | 1.95 (1.08,3.52) | 0.026 | 1.75 (0.91,3.37) | 0.094 | 1.62 (0.75,3.47) | 0.216 |
Without mixed plaque | |||||||||
rSSlow | 4 (8.7) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) |
rSSmid | 18 (17.3) | 2.01 (0.68,5.94) | 0.207 | 1.22 (0.5,2.96) | 0.667 | 1.81 (0.6,5.44) | 0.294 | 2.03 (0.64,6.46) | 0.232 |
rSShigh | 13 (28.3) | 3.56 (1.16,10.92) | 0.026* | 2.5 (1.04,6.05) | 0.041* | 2.46 (0.76,7.96) | 0.132 | 2.91 (0.8,10.65) | 0.106 |
Trend test | 35 (17.9) | 1.85 (1.12,3.06) | 0.017* | 1.67 (1.07,2.62) | 0.025* | 1.52 (0.89,2.59) | 0.126 | 1.65 (0.9,3.01) | 0.105 |
With mixed plaque | |||||||||
rSSlow | 4 (15.4) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) | 1(reference) |
rSSmid | 4 (13.3) | 0.81 (0.2,3.26) | 0.772 | 2.94 (0.35,24.81) | 0.321 | 1.07 (0.18,6.23) | 0.941 | 1.24 (0.06,26.5) | 0.891 |
rSShigh | 5 (22.7) | 1.48 (0.4,5.52) | 0.558 | 1.12 (0.07,19.32) | 0.937 | 5.05 (0.95,26.95) | 0.058 | 14.66 (0.65,330.23) | 0.091 |
Trend test | 13 (16.7) | 1.24 (0.61,2.5) | 0.553 | 1.08 (0.37,3.14) | 0.881 | 2.44 (0.99,6.01) | 0.054 | 4.67 (0.85,25.7) | 0.076 |