Thrombosis Journal

Table 4 Cox regression analysis of PCSK9, PT status with MACEs

From: Association of circulating proprotein convertase subtilisin/kexin type 9 concentration, prothrombin time and cardiovascular outcomes: a prospective cohort study

Variables	Events/subjects	HR(95%CI)
Variables	Events/subjects	Crude model	p	Adjusted model	p
PCSK9
Low PCSK9	72/1146	1 (Reference)	/	1 (Reference)	/
High PCSK9	114/1147	1.526 (1.136,2.049)	0.005	1.393 (1.023,1.896)	0.035
PT
High PT	77/1178	1 (Reference)	/	1 (Reference)	/
Low PT	109/1115	1.512 (1.129,2.024)	0.006	1.396 (1.029,1.895)	0.032
PCSK9 + PT
Low PCSK9 + High PT	37/682	1 (Reference)	/	1 (Reference)	/
Low PCSK9 + Low PT	35/464	1.415 (0.891,2.246)	0.141	1.369 (0.854,2.193)	0.192
High PCSK9 + High PT	40/496	1.43 (0.914,2.236)	0.117	1.363 (0.864,2.149)	0.183
High PCSK9 + Low PT	74/651	2.049 (1.381,3.041)	< 0.001	1.815 (1.193,2.762)	0.005

Adjusted model was adjusted for age, gender, CAD, diabetes, family history of CAD, TC, LDL, HbA1C, fibrinogen. MACEs, major adverse cardiovascular events; PCSK9, proprotein convertase subtilisin/kexin type 9; PT prothrombin time, HR hazard ratio, CI confidence interval, CAD coronary artery disease, TC total cholesterol, HDL-C, LDL-C low-density lipoprotein cholesterol, HbA1C hemoglobin A1C. p < 0.05 suggested significant difference

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