Fig. 1
From: NETosis and SARS-COV-2 infection related thrombosis: a narrative review
NETs formation can lead to vascular endothelial cells dysfunction. NETs contain decondensed chromatin, citrullinated-histones and proteolytic peptides such as myeloperoxidase (MPO), neutrophil elastase (NE) and high mobility group protein B1 (HMGB1), peptidyl arginine deaminase 4 (PAD4). NETs interaction to neutrophils and platelets lead to immunothrombosis formation