Fig. 4

Antiplatelet reversal with epinephrine. An ex vivo experiment was performed to test the ability of epinephrine to reverse the antiplatelet effects of cangrelor. Each of the four graphs displays a different platelet function test (upper left: MEA (n = 11), upper right: VASP-P (n = 10), lower left: PFA ADP (n = 2), lower right PFA P2Y (n = 11)). The three columns in each graph represent the spiked concentration of epinephrine: no epinephrine added (left), epinephrine in a concentration of 200 ng/mL (middle) and epinephrine in a concentration of 500 ng/mL (right). Of note, in the experiment using the PFA ADP test, samples from just two subjects were tested and therefore no statistical significance was calculated. Two asterisks (**) describe a p value of ≤0.01, whereas three asterisks (***) describe a p value of ≤0.001. Data are shown as median and interquartile range