Table 1 Baseline characteristics
Characteristic | Edoxaban (n = 7,975) | Phenprocoumon (n = 13,319) | ASDa |
|---|---|---|---|
Demographics | |||
Age (mean ± SD) | 73.70 [10.81] | 76.56 [8.90] | 0.30 |
Male | 55.5% | 52.5% | 0.06 |
Health Resource Utilization | |||
Number of all-cause hospitalizations (mean ± SD) | 0.97 [1.20] | 1.11 [1.33] | 0.11 |
Number of hospital days (mean ± SD) | 7.92 [15.94] | 10.86 [18.10] | 0.17 |
Number of all-cause hospitalizations within 30 days prior first dispensation (mean ± SD) | 0.46 [0.56] | 0.42 [0.57] | 0.07 |
Number of stroke/SE-related hospitalizations within 30 days prior first dispensation (mean ± SD) | 0.03 [0.17] | 0.03 [0.18] | 0.02 |
Number of outpatient cases (mean ± SD) | 13.14 [7.33] | 14.29 [7.59] | 0.15 |
Number of unique medications (mean ± SD) | 8.61 [5.08] | 9.86 [5.25] | 0.24 |
Risk Scores | |||
CHA2DS2-VASc (mean ± SD) | 3.56 [1.64] | 4.15 [1.52] | 0.38 |
Modified HAS-BLED (mean ± SD) | 2.52 [1.15] | 2.82 [1.06] | 0.27 |
Charlson Comorbidity Index (mean ± SD) | 2.91 [2.59] | 3.67 [2.72] | 0.28 |
Comorbidities | |||
Coronary heart disease | 33.6% | 47.6% | 0.29 |
Congestive heart failure | 28.9% | 41.7% | 0.27 |
Renal insufficiency | 18.4% | 28.7% | 0.24 |
Diabetes mellitus | 30.3% | 37.3% | 0.15 |
Hypertension | 83.3% | 89.4% | 0.18 |
Ischemic stroke or transient ischemic attack | 9.6% | 12.0% | 0.08 |
Myocardial infarction | 4.4% | 8.3% | 0.16 |
Major bleeding | 1.0% | 1.7% | 0.06 |
Any bleeding event | 6.7% | 10.4% | 0.13 |
Concomitant Medication | |||
Antiplatelet drugs | 21.8% | 24.3% | 0.06 |
ASA | 17.8% | 18.5% | 0.02 |
NSAIDs | 34.2% | 31.7% | 0.05 |
ß-blockers | 78.8% | 82.0% | 0.08 |
Proton-pump inhibitors | 39.5% | 44.9% | 0.11 |