Table 2 Standard thromboelastometric tests in patients with chronic liver disease and healthy controls (anova with bonferroni adjustment)

EXTEM

(Reference Ranges)

 CT (38–79 s)

55 (51–60)

62 (56–74)

71 (64–77)

 < 0.05, a vs. b and c

 CFT (34–159 s)

80 (72–92)

146 (100–181)

139 (94–214)

 < 0.05, a vs. b and c

 TT20 (CT + CFT)

141 (126–149)

221 (159–255)

205 (168–281)

 < 0.01, a vs. b and c

 ALPHA (63–83˚)

74 (71–75)

67 (59–74)

65 (56–71)

 < 0.05, a vs. b and c

 A5

48 (43–52)

32 (28–38)

30 (19–39)

 < 0.01, a vs. b and c

 A10 (43–65 mm)

58 (54–60)

43 (37–48)

44 (35–54)

 < 0.01, a vs. b and c

 MCF (50–72 mm)

65 (63–67)

52 (48–57)

53 (46–57)

 < 0.01, a vs. b and c

 G

9108 (8534–10,267)

5402 (4661–6759)

5923 (4476–7880)

 < 0.01, a vs. b and c

 TPI

2.33 (1.82–2.81)

0.69 (0.53–1.30)

0.84 (0.42–1.37)

 < 0.01, a vs. b and c

INTEM

(Reference Ranges)

 CT (100–240 s)

182 (167–184)

190 (163–218)

215 (194–247)

ns

 CFT (30–110 s)

67 (61–83)

138 (103–172)

136 (93–213)

 < 0.01, a vs. b and c

 TT20 (CT + CFT)

255 (239–275)

326 (306–349)

369 (312–442)

 < 0.01, a vs. b and c

 ALPHA (70–83˚)

76 (73–77)

67 (60–71)

62 (55–70)

 < 0.01, a vs. b and c

 A5

46 (42–49)

33 (28–37)

32 (24–38)

 < 0.01, a vs. b and c

 A10 (44–66 mm)

57 (54–59)

43 (37–47)

41 (33–47)

 < 0.01, a vs. b and c

 MCF (50–72 mm)

62 (61–65)

50 (45–56)

51 (43–55)

 < 0.01, a vs. b and c

 G

8322 (7988–9442)

5278 (4313–6558)

5192 (3918–6360)

ns

 TPI

2.43 (1.79–3.04)

0.72 (0.51–1.11)

0.80 (0.35–1.30)

 < 0.01, a vs. b and c

 CT-Ratio (INTEM/HEPTEM)

1.04 (0.95–1.08)

0.96 (0.89–1.07)

1.03(1.01–1.25)

ns

FIBTEM

(Reference Ranges)

 CT

52 (49–57)

61 (50–67)

61 (51–77)

ns

 A5

16 (12–17)

14 (10–16)

10 (8–14)

ns

 A10 (7–23 mm)

16 (13–19)

14 (11–16)

10 (8–16)

ns

 MCF (9–25 mm)

17 (14–19)

15 (12–18)

11 (9–17)

ns

Velocity parameter

 EXTEM AUC

6446 (6263–6731)

5152 (4777–5692)

5405 (4705–6049)

 < 0.01, a vs. b and c

 EXTEM maxV

15 (13–17)

11 (8–14)

10 (8–14)

 < 0.01, a vs. b and c

 EXTEM maxV-t

103 (73–118)

92 (63–145)

105 (85–129)

ns

 FIBTEM AUC

1699 (1409–2161)

1532 (1206–1817)

1095 (965–1601)

ns

 FIBTEM maxV

14 (11–16)

10 (8–16)

8 (6–11)

ns

 FIBTEM maxV-t

58 (53–69)

66 (61–77)

72 (60–80)

ns

 INTEM AUC

6257 (6082–6427)

5178 (4662–5687)

5241 (4395–5618)

 < 0.01, a vs. b and c

 INTEM maxV

18 (15–20)

11 (9–13)

10 (7–13)

 < 0.01, a vs. b and c

 INTEM maxV-t

205 (193–224)

205 (180–243)

254 (214–288)

0.05, b vs. c

Fibrinoliysis parameter

 EXTEM LI30 (94–100%)

100 (100–100)

100 (100–100)

100 (100–100)

ns

 EXTEM LI45

97 (96–98)

99 (96–100)

100 (99–100)

 < 0.05 a vs. c

 EXTEMLI60 (86–100%)

93 (90–96)

96 (91–98)

99 (96–100)

 < 0.05 a vs. c

 EXTEM ML (< 15% at 60 min after CT)

7.0 (4.0–9.0)

4.0 (2.0–8.5)

1.0 (0.0–3.2)

 < 0.05 a vs. c

 FIBTEM LI30

100 (100–100)

100 (99–100)

100 (97–100)

ns

 FIBTEM LI45

100 (100–100)

100 (98–100)

100 (97–100)

ns

 FIBTEM LI60

100 (99–100)

100 (97–100)

100 (96–100)

ns

 FIBTEM ML

0 (0–0.5)

0 (0–2.5)

0 (0–3.5)

ns

 ΔLI60 (FIBTEM – EXTEM)

6(4–9)

2.5(1–6.7)

0.5(-2.7–3.2)

 < 0.05 a vs. c