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Table 1 Characteristics of patients in different prophylaxis groups

From: Modern thromboprophylaxis protocol based on guidelines applied in a respiratory intensive care unit: a single-center prospective cohort study

 

Overall (N = 884)

Mechanical prophylaxis group (N = 93)

Pharmacological prophylaxis group (N = 387)

Pharmacological combined mechanical prophylaxis group (N = 404)

P-value

Age (years, IQR)

61 (48, 70)

59 (46, 70)

62 (50, 73)

61 (47, 69)

0.074

  ≥ 70 years, n (%)

250 (28.3)

24 (25.8)

127 (32.8) †

99 (24.5) †

0.029

Male, n (%)

591 (66.9)

64 (68.8)

252 (65.1)

275 (68.1)

0.626

BMI (kg/m2, IQR)

23.7 (20.8, 26.7)

23.7 (21.3, 26.7)

23.4 (20.5, 26.7)

23.9 (21.2, 26.7)

0.402

 BMI ≥ 30 kg/m2, n (%)

84 (9.7)

11 (11.8)

35 (9.2)

38 (9.6)

0.742

Underlying disease, n (%)

 Hypertension

366 (41.4)

44 (47.3)

157 (40.6)

165 (40.8)

0.478

 Diabetes mellitus

192 (21.7)

28 (30.1)

78 (20.2)

86 (21.3)

0.109

 Coronary artery disease

112 (12.7)

9 (9.7)

56 (14.5)

47 (11.6)

0.319

 Chronic heart failure

125 (14.1)

6 (6.5)

56 (14.5)

63 (15.6)

0.071

 Chronic renal dysfunction

78 (8.8)

9 (9.7)

26 (6.7)

43 (10.6)

0.146

 Hepatic failure due to cirrhosis

43 (4.9)

3 (3.2)

13 (3.4)

27 (6.7)

0.084

 Solid-organ malignancy

58 (6.6)

7 (7.5)

21 (5.4)

30 (7.4)

0.503

 VTE history

25 (2.8)

3 (3.2)

8 (2.1)

14 (3.5)

0.444

Cause of admission, n (%)

 ARDS

274 (31.0)

18 (19.4)

109 (28.2)

147 (36.4)*

0.002

 Pneumonia

593 (67.1)

65 (69.9)

234 (60.5)†

294 (72.8)†

0.001

 IPA

25 (2.8)

2 (2.2)

18 (4.7)†

5 (1.2)†

0.012

 AECOPD

101 (11.4)

3 (3.2)

60 (15.5)*

38 (9.4)

0.001

 Acute exacerbation of asthma

17 (1.9)

0 (0)

12 (3.1)

5 (1.2)

0.075

 Sepsis

73 (8.3)

10 (10.8)

24 (6.2)

39 (9.7)

0.137

 Post-surgery

90 (10.2)

13 (14.0)

32 (8.3)

45 (11.1)

0.182

Caprini score, n%

 High or extremely high risk (≥3)

788 (89.2)

82 (88.2)

342 (88.6)

364 (90.1)

0.746

Padua score (High risk), n (%)

306 (34.7)

40 (43.0)

98 (25.4)*

168 (41.6)

< 0.001

APACHE II

14 (10, 20)

16 (12, 22)

14 (10, 19)

16 (11, 22)

0.742

  1. *P value for the difference between this group and the other two groups was less than 0.0167
  2. †P value for the difference between the pharmacological prophylaxis group and pharmacological combined mechanical prophylaxis group was less than 0.0167
  3. AECOPD acute exacerbation of chronic obstructive pulmonary disease, ARDS acute respiratory distress syndrome, BMI body mass index, IPA invasive pulmonary aspergillosis, OSAHS obstructive sleep apnea-hypopnea syndrome
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Thrombosis Journal

ISSN: 1477-9560

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