The efficacy of tranexamic acid treatment with different time and doses for traumatic brain injury: a systematic review and meta-analysis

Table 2 The risk of bias of studies

Outcomes	Heterogeneity (I²), P-value	Harbord’s test	Egger’s test	number of studies
Mortality	48%, 0.04	0.4865	0.4832	10
severe TBI (GCS 3 to 8)	0%, 0.79	0.3983	0.3346	4
GOS < 4	71%, 0.004	0.5533	0.5925	6
Neurosurgical Intervention	0%, 0.73	0.3403	0.3356	5
Rebleeding	0%, 0.73	0.5421	0.5066	4
adverse event^a	50%, 0.08	0.1543	0.2468	6
Vascular occlusive events	0%, 0.37	0.8878	0.9214	3
Pulmonary embolism	64%, 0.06	0.2980	0.7334	4
Deep vein thrombosis	0%, 0.60	0.6228	0.8206	4
Neurological complications	27%, 0.25	0.0328	0.0682	4

TBI Traumatic brain injury, GCS Glasgow coma scale, GOS Glasgow outcome scale
^aindicates Vascular occlusive events + Pulmonary embolism + Deep vein thrombosis + Neurological complications

ISSN: 1477-9560