Fig. 1

a Time course of clinical and laboratory markers of transplant-associated thrombotic microangiopathy is shown. Lactate dehydrogenase (LDH), haptoglobin, urine protein:creatinine ratio, schistocytes/hpf are plotted and events such as diarrhea, radiological colitis, and the number of anti-hypertensive medications and treatment of thrombotic microangiopathy with defibrotide and narsoplimab are shown. LDH is shown on the left y-axis and haptoglobin, urine protein:creatinine ratio, and schistocytes are shown on the right y-axis. b Lactate dehydrogenase (LDH) pre-narsoplimab and on treatment with narsoplimab are shown. A statistically significant difference in the LDH levels was observed on the unpaired t-test (p < 0.0001). c Hemoglobin and platelet trends during the early episode of TA-TMA are shown. The patient was red cell-dependent and platelet-dependent until day+ 70 and day+ 77 respectively. Abbreviations: ANC – absolute neutrophil count, LDH – lactate dehydrogenase, Hb – Hemoglobin, tww – twice a week, thw – thrice a week, onw – once a week, vol – volume