Fig. 1
From: Platelet indices and blood pressure: a multivariable mendelian randomization study
Directed acyclic graphs depicting the effects between platelet indices and BP. The analysis undertaken in this study used the MR method with 3 key assumptions satisfied. A: Platelet index SNPs were used as genetic instruments to investigate the causal effect of platelet indices on BP. B: BP SNPs were used as genetic instruments to investigate the causal effect of BP on platelet indices. Dashed lines indicate that SNPs are independent of any confounding variables between the results. C: Multivariable MR was applied to estimate the effect of platelet indices on BP. Dashed lines indicate that the traits are correlated (model 2).