Fig. 1

High-throughput transcriptome sequencing analysis to screen key genes involved in DVT. A, DVT in the sham-operated mice and DVT mice observed by HE staining. White triangles indicate the platelet bundles, red triangles indicate clustered red blood cells, and yellow arrows indicate the blood vessel wall. B, Representative image of thrombosis in the inferior vena cava of the sham-operated mice and DVT mice. C & D, Measurement results of the length (C) and weight (D) of thrombus in the sham-operated mice and DVT mice (n = 6). E-G, The levels of inflammatory factors IL-1β (E), IL-6 (F) and IL-8 (G) in mouse femoral venous blood of the sham-operated mice and DVT mice measured by ELISA (n = 6). H & I, Volcano plots of differentially expressed lncRNAs (H) and mRNAs (I) analyzed by high-throughput sequencing (Black dots represent genes not differentially expressed, red dots represent the upregulated genes, and green dots represent downregulated genes. n = 3). J, The Crnde expression in DVT mice measured by RT-qPCR (n = 6). *** p < 0.001 vs. the sham group