Table 2 Sensitivity analyses for associations of genetically determined ICAM-4 levels with ischemic stroke and its subtypes

Ischemic stroke

Penalized IVW

OR

1.04 (1.01–1.07)

0.006

Maximum Likelihood

OR

1.04 (1.01–1.07)

0.003

MR-RAPS

OR

1.04 (1.01–1.07)

0.003

MR-Egger

OR

0.98 (0.91–1.06)

0.657

Odds (intercept)

1.03 (0.99–1.07)

0.118

Cardioembolic stroke

Penalized IVW

OR

1.08 (1.02–1.14)

0.004

Maximum Likelihood

OR

1.08 (1.03–1.14)

0.003

MR-RAPS

OR

1.08 (1.03–1.14)

0.003

MR-Egger

OR

0.95 (0.82–1.10)

0.484

Odds (intercept)

1.06 (1.00-1.14)

0.066

Large artery stroke

Penalized IVW

OR

1.06 (0.99–1.13)

0.090

Maximum Likelihood

OR

1.06 (0.99–1.13)

0.088

MR-RAPS

OR

1.06 (0.99–1.13)

0.091

MR-Egger

OR

0.89 (0.74–1.08)

0.228

Odds (intercept)

1.09 (0.90–1.05)

0.055

Small vessel stroke

Penalized IVW

OR

1.03 (0.97–1.09)

0.338

Maximum Likelihood

OR

1.03 (0.97–1.09)

0.342

MR-RAPS

OR

1.03 (0.97–1.09)

0.339

MR-Egger

OR

1.10 (0.92–1.31)

0.300

Odds (intercept)

0.97 (0.90–1.05)

0.452