Item | Survivors n (%) | Non-survivors n (%) | p† |
---|---|---|---|
N | 148 (80) | 37 (20) | |
TMA score items | |||
Hb < 10.0 g/dL* | 145 (98.0) | 36 (97.3) | 1.000 |
PLT < 150 × 109/L | 146 (98.6) | 37 (100.0) | 1.000 |
Renal failure | 137 (92.6) | 32 (86.5) | 0.322 |
Extrarenal organ failure | 92 (62.2) | 30 (81.1) | 0.033 |
Positive aHUS score items | |||
Past history of TMA | 15 (10.1) | 4 (10.8) | 1.000 |
1 time | 15 (10.1) | 4 (10.8) | |
≥ 2 times | 0 (0.0) | 0 (0.0) | |
Family history of TMA, n/N reported (%) | 9/141 (6.1) | 1/35 (2.7) | 0.689 |
1 family member | 7/141 (4.7) | 1/35 (2.7) | |
≥ 2 family members | 2/141 (1.4) | 0/35 (0.0) | |
Age at onset of TMA | |||
< 10 years | 37 (25.0) | 12 (32.4) | 0.673 |
≥ 10 to < 63 years | 77 (52.0) | 18 (48.6) | |
≥ 63 years | 34 (23.0) | 7 (18.9) | |
Trigger | 36 (24.3) | 10 (27.0) | 0.831 |
Exclusion aHUS score items | |||
Bloody stool | 17 (11.5) | 6 (16.2) | 0.414 |
ADAMTS13 < 10% | 2 (1.4) | 0 (0.0) | 1.000 |
Underlying diseases | 15 (10.1) | 15 (40.5) | < 0.001 |
Malignant tumor | 11 (7.4) | 11 (29.7) | |
HSCT | 11 (7.4) | 10 (27.0) | |
Chemotherapy | 1 (0.7) | 4 (10.8) | |
Acute pancreatitis | 0 (0.0) | 0 (0.0) | |
D-dimer > 20 μg/mL | 0 (0.0) | 0 (0.0) | - |
WBC > 16,000/mL | 1 (0.7) | 1 (2.7) | 0.360 |
Total score, median (range) | 10 (3–16) | 9 (4–13) | 0.055 |