Table 2 Aim 1: ex vivo and in vivo thrombin generation compared between patients with lower-leg injury and controls

Thrombin generation

(N = 89)

(N = 88)

 ETP (nM IIa * min)

566.0 (202.2)

451.4 (239.4)

114.6 (48.8 to 180.3)

120.0 (55.0 to 185.1)

149.7 (67.7 to 231.6)

 Thrombin peak (nM)

152.3 (59.4)

117.3 (67.4)

35.0 (16.1 to 53.8)

36.6 (17.8 to 55.3)

44.8 (21.1 to 68.5)

 Lag time (min)

2.0 (0.5)

2.1 (0.6)

-0.1 (-0.3 to 0.0)

-0.1 (-0.3 to 0.0)

-0.1 (-0.3 to 0.1)

 Velocity index (nM/min)

72.8 (33.8)

55.7 (37.5)

17.0 (6.4 to 27.6)

18.0 (7.4 to 28.6)

22.9 (9.4 to 36.4)

In vivo markers

(N = 66)

(N = 28)

 TAT complexes (ug/L)^a

5.7 (4.8 to 6.7)^a

2.3 (2.1 to 2.5)^a

2.5 (1.9 to 3.2)^a

2.3 (1.7 to 3.0)^a

2.3 (1.7 to 3.1)^a

 Prothrombin fragment 1 + 2 (pmol/L)^a

260.7 (231.2 to 294.0)^a

242.7 (218.6 to 269.3)^a

1.1 (0.9 to 1.3)^a

1.0 (0.8 to 1.2)^a

1.0 (0.8 to 1.3)^a

 Fibrinopeptide A (ng/mL)

143.9 (91.5)

95.1 (64.3)

48.8 (11.0 to 86.7)

43.8 (5.9 to 81.8)

57.2 (14.5 to 99.9)