Enhanced in vivo and ex vivo thrombin generation after lower-leg trauma, but not after knee arthroscopy

Thrombosis Journal

Table 4 Aim 2: ex vivo and in vivo thrombin generation in knee arthroscopy patients measured pre- and postoperatively

	Mean (SD)^b		Paired mean change (95%CI)	Paired mean change (95%CI) ^c
	Preoperative	Postoperative	Paired mean change (95%CI)	Paired mean change (95%CI) ^c
Thrombin generation (N = 85)^a
ETP (nM IIa * min)	444.4 (240.3)	473.1 (260.9)	28.7 (-4.1 to 61.5)	30.2 (-20.5 to 80.9)
Thrombin peak (nM)	116.0 (67.9)	121.0 (72.0)	5.0 (-4.0 to 13.9)	3.4 (-10.7 to 17.4)
Lag time (min)	2.2 (0.6)	2.0 (0.5)	-0.1 (-0.2 to 0.0)	-0.1 (-0.2 to 0.0)
Velocity index (nM/min)	55.5 (37.9)	58.7 (42.1)	3.2 (-2.0 to 8.3)	0.9 (-6.6 to 8.4)
In vivo markers (N = 28)
TAT complexes (ug/L)^b	2.3 (2.1 to 2.5)^b	2.1 (1.9 to 2.3)^b	-0.2 (-0.5 to 0.2)	-0.2 (-0.6 to 0.2)
Prothrombin fragment 1 + 2 (pmol/L)^b	242.7 (218.6 to 269.3)^b	226.6 (201.4 to 255.1)^b	-14.9 (-38.4 to 8.5)	-12.2 (-44.8 to 20.4)
Fibrinopeptide A (ng/mL)	95.1 (64.3)	101.2 (64.0)	6.1 (-20.8 to 33.1)	18.7 (-14.1 to 51.4)

^aThrombin generation was not measured in the postoperative samples of three patients due to lack of plasma (n = 2) or presence of clots in plasma (n = 1)
^bThis symbol and italics indicate geometric means (with 95%CIs) in case of ln-retransformation due to skewed data
^cPaired mean changes corrected for time of blood sampling (diurnal variation); calculated using LMM

ISSN: 1477-9560