Table 2 Baseline characteristics of the patients from single-arm trials
Study | Females, n (%) | Age, years, Mean (SD) or Median (range) | Platelet counts per 109/L (SD or range) | Previous splenectomy, n (%) | Number of previous treatments, n (%) |
|---|---|---|---|---|---|
Tomiyama et al. 2012 | 15 (65) | 60 (26–72) | 17 (10–24) | 16 (70) | 19 (83) |
Brynes et al. 2017 | 104 (64) | 42 (18–80) | 59 (36)a | 37 (23) | 0 (0) |
Bussel et al. 2013 | 45 (68) | 51 (20–79) | 4 (6)b | 20 (30) | ≥ 3: 29 (44) |
G´omez-Almaguer et al. 2014 | 6 (50) | 50 (20–80) | 7 (2–28) | NA | NA |
Haselboeck et al. 2013 | 9 (90) | 30 (20–58) | NA | 0 (0) | Median number of treatments: 2 (1–3) |
Kim et al. 2015 | 11 (61) | 55 (30–71) | 14 (1–28) | 4 (22) | Median number of treatments: 3 (2–9) |
Liu et al. 2022 | 112 (75) | 44 (15) | 20 (15) | 25 (17) | ≥ 1: 76 (51) |
Saleh et al. 2013 | 198 (66) | 50 (18–86) | 128 (43)a | 115 (38) | ≥ 3: 47 (16) |
Tripathi et al. 2014 | 15 (60) | 27 (9) | 14 (5) | 0 (0) | 0 (0) |
Wong et al. 2017 | 201 (67) | 49 (16) | 211 (70)c | 115 (38) | ≥ 3: 160 (53) |
van Dijk et al. 2023 | 7 (44) | 53 (14) | 23 (9–27) | 2 (12) | NA |
Mei et al. 2022 | 25 (68) | 40 (28–53) | 14 (11–22) | 3 (8) | ≥ 1: 37 (100) |
Mei et al. 2021 | 241 (88) | 41 (18–74) | 13 (1–29) | 29 (11) | NA |
Bussel et al. 2014 | 38 (72) | 50 (18) | 15 (28)a | 17 (32) | NA |
Al-Samkari et al. 2022 | 23 (59) | 46 (14) | 18 (46)a | 11 (28) | ≥ 1: 15 (38) |
Bussel et al. 2006 | 17 (71) | 45 (21–65) | 9 (4–31) | 19 (79) | 1–3: 9 (38) 4–6: 12 (50) > 6: 3 (13) |
Gernsheimer et al. 2010 | 81 (80) | 52 (21–88) | 16 (2–31) | 83 (82) | ≥ 3: 79 (78) |
Bussel et al. 2009 | 96 (67) | 53 (21–89) | 17 (1–50) | 86 (60) | ≥ 1: 32 (22) |
Janssens et al. 2015 | 244 (60) | 56 (18–93) | 14 (0–170) | 208 (51) | ≥ 1: 208 (51) |
Kuter et al. 2013 | 184 (63) | 54 (17) | 35 (15–100) | 95 (33) | ≥ 1: 37 (13) |
Mihaylov et al. 2020 | 56 (56) | 45 (27–58) | 19 (8–42) | 23 (23) | ≥ 3: 49 (49) |
Newland et al. 2006 | 10 (63) | 50 (20–84) | 15 (6–31) | 13 (81) | NA |
Newland et al. 2015 | 44 (59) | 39 (29–57) | 20 (12–25) | 0 (0) | ≥ 1: 44 (57) |
Park et al. 2016 | 12 (67) | 40.5 (26–73) | 14 (4–30) | 4 (22) | ≥ 3: 8 (44) |
Reiser et al. 2021 | 50 (48) | 67 (55–72) | 29 (15–78) | 9 (9) | ≥ 1: 85 (89) |
Shirasugi et al. 2012 | 31 (71) | 56 (25–81) | 17 (3–32) | 17 (39) | NA |
Singh et al. 2022 | 33 (66) | 36 (12) | NA | NA | ≥ 1: 50 (100) |
Steurer et al. 2016 | 183 (54) | 62 (46–72) | 20 (9–35) | 116 (34) | ≥ 3: 186 (55) |
Cai et al. 2017 | 44 (57) | 37 (3–74) | 10 (0–44) | NA | NA |