Table 5 Subgroup analyses for pooled rates of overall thrombotic events in single-arm trials

Thrombopoietic agents

Overall

29

2.2%

(1.0 − 3.7%)

75.625

< 0. 001

NA

Treatment duration

< 0. 001

≤ 6 months

16

0.1%

(0.0 − 0.7%)

11.109

0.326

> 6 months

12

4.7%

(2.9 − 6.8%)

76.437

< 0.001

Excluded patients with thrombotic history

0.257

Yes

14

1.4%

(0.1 − 3.7%)

77.771

< 0.001

No

15

3.0%

(1.3 − 5.2%)

69.816

< 0.001

Age, years

0.132

≤ 50

18

1.3%

(0.2 − 3.0%)

70.149

< 0.001

> 50

11

3.7%

(1.6 − 6.6%)

77.145

< 0.001