Fig. 5
From: Circulating LPS from gut microbiota leverages stenosis-induced deep vein thrombosis in mice
Identification of protein downstream effectors of LPS in plasma for DVT in mice. Quantitative proteomics was performed to quantify plasma proteins in LPS-treated and XOS-treated mice, and their controls (CON). (A & B) Volcano plots illustrate the upregulated (red dots) and downregulated (green dots) proteins in LPS-treated and XOS-treated samples when compared to their controls. (C) The plasma proteins that were reversely regulated in LPS-treated and XOS-treated groups are listed. (D & E) Western blotting was conducted to compare TSP1 levels in the plasma of treated mice and their controls. (F-H) Mice were intravenously injected with either TSP1 or saline buffer (CON), followed by the partial IVC ligation for 6 h. The IVC tissues were collected and the formed thrombi in the IVC were quantified and imaged (n = 10). Data are shown as mean ± SD. (**, p < 0.01)