From: Tranexamic acid for haemostasis and beyond: does dose matter?
 | Clinical Indication | Dose | References | Notes |
---|---|---|---|---|
Haemostatic indications | Orthopaedic surgery | high dose IV TXA: ≥ 20 mg/kg or > 1 g and high dose topical TXA: > 1.5 g |  | |
Cardiac surgery | 50Â mg/kg bolus | [36] | Â | |
Trauma | IV 1 g bolus (± pre-hospital) then 1 g infusion over 8 h |  | ||
Obstetric bleeding | IV 1 g bolus (± second bolus if ongoing/recurrent bleeding) | [37] |  | |
Dental bleeding in patients with a bleeding disorder | TXA mouthwash (50 mg/mL): 10 mL 4 times/day IV: 0.5–1 g 2–3 times/day Oral: 1–1.5 g 2–3 times/day |  | ||
Hereditary haemorrhagic telangiectasia | 3Â g in 24Â h | [123] | Â | |
Gastrointestinal bleeding | 1Â g over 1Â h then 3Â g over 24Â h | [124] | Negative study | |
Intracerebral haemorrhage | 1Â g over 10Â min then 1Â g over 8Â h | Negative study | ||
Malignant thrombocytopenia | 1Â g IV 8 hourly or 1.5Â g orally 8 hourly | [127] | Negative study | |
Haemostatic indications under investigation | Reduce recurrent cerebral bleeding in chronic amyloid angiopathy | 20Â mg/mL for 6Â months | [67] | Evaluated in mice overexpressing the mutant human amyloid precursor protein |
Non-haemostatic indications | Hereditary angioedema | 2–4 g in 24 h | [128] | Can be used therapeutically and as prophylaxis |
Melasma | 500–750 mg in 24 h | [112] |  | |
Non-haemostatic indications under Investigation | Reduce infection after gastrointestinal surgery | 15Â mg/kg bolus before surgical incision, then infusion at 5Â mg/kg/h until the end of surgery | Â | TRIGS Clinical Trial https://www.trigs.org.au/ |
Reduce delirium following gastrointestinal surgery | 15Â mg/kg bolus before surgical incision, then infusion at 5Â mg/kg/h until the end of surgery | Â | TRIGS-D Clinical Trial https://www.trigs.org.au/trigs_d | |
Reduce severity of necrotising deep tissue infection | 2Â g daily for 4Â days | Â | TRITON Clinical Trial https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=382739&isReview=true |