The serum lipid profiles in immune thrombocytopenia: Mendelian randomization analysis and a retrospective study

Thrombosis Journal

Table 1 Results of MR analysis of five lipids on platelet properties

outcome	exposure	Inverse variance weighted		MR Egger		Weighted median		Inverse variance weighted (multiplicative random effects)
outcome	exposure	OR	P	OR	P	OR	P	OR	P
PDW	ApoA1	0.95 (0.9, 1)	0.04992471	1 (0.93, 1.09)	0.93092994	0.95 (0.91, 1)	0.03930573	0.95 (0.9, 1)	0.050
PDW	ApoB	1.06 (1, 1.12)	0.03681477	1.04 (0.97, 1.11)	0.31256384	1.05 (1.01, 1.09)	0.0142602	1.06 (1, 1.12)	0.037
PDW	HDL-C	0.88 (0.83, 0.92)	6.7162E-07	0.86 (0.8, 0.93)	0.00025656	0.93 (0.9, 0.98)	0.00225869	0.88 (0.83, 0.92)	< 0.001
PDW	triglycerides	1.27 (1.21, 1.32)	6.3416E-26	1.32 (1.24, 1.41)	4.0662E-14	1.29 (1.23, 1.35)	7.1012E-29	1.27 (1.21, 1.32)	< 0.001
MPV	LDL-C	1.05 (1, 1.1)	0.02980394	1.06 (0.99, 1.13)	0.12709535	1.07 (1.03, 1.11)	0.00031889	1.05 (1, 1.1)	< 0.001

MR: Mendelian randomization, PDW: Platelet distribution width, MPV: Mean platelet volume, ApoA1: apolipoprotein A-1, ApoB: apolipoprotein B, HDL-C: high-density-lipoprotein cholesterol, LDL-C: low-density-lipoprotein cholesterol

ISSN: 1477-9560