The serum lipid profiles in immune thrombocytopenia: Mendelian randomization analysis and a retrospective study

Xu, Pengcheng; Han, Shouqing; Hou, Ming; Zhao, Yajing; Xu, Miao

doi:10.1186/s12959-023-00551-x

Thrombosis Journal

Table 5 Correlation analysis of baseline platelet indices and serum lipid profile

From: The serum lipid profiles in immune thrombocytopenia: Mendelian randomization analysis and a retrospective study

		PC			PDW
		Total	Male	Female	Total	Male	Female	Total	Male	Female	Total	Male	Female
Cho	r	-0.021^P	-0.028^P	0.035^P	0.099^P	0.079^S	0.189^S	0.066^S	0.049^S	0.031^S	-0.086^P	-0.111^P	-0.058^S
	p	0.673	0.718	0.597	0.221	0.514	0.085	0.416	0.685	0.778	0.289	0.359	0.598
HDL-C	r	-0.036^P	-0.062^P	-0.021^P	0.178^*P	0.215^S	0.164^P	0.094^S	0.197^S	0.024^S	-0.066^P	-0.244^*P	0.019^P
	p	0.466	0.424	0.743	0.028	0.074	0.135	0.244	0.102	0.827	0.413	0.042	0.866
LDL-C	r	-0.030^P	-0.026^P	-0.035^P	0.059^P	-0.009^S	0.093^P	0.077^S	0.053^S	0.082^S	-0.079^P	-0.062^P	-0.101^P
	p	0.543	0.743	0.594	0.468	0.943	0.403	0.343	0.666	0.458	0.329	0.613	0.359
sdLDL	r	0.005^P	0.063^P	-0.039^P	-0.023^P	-0.078^S	0.051^P	-0.015^S	-0.063^S	0.043^S	-0.066^P	0.040^P	-0.148^P
	p	0.925	0.426	0.551	0.778	0.521	0.649	0.858	0.603	0.697	0.420	0.740	0.182
APOA1	r	-0.052^S	-0.047^S	-0.047^S	-0.042^S	0.102	-0.126^S	-0.216^S	-0.136^S	-0.158^S	-0.064^S	-0.257^S	-0.072^S
	p	0.596	0.759	0.722	0.782	0.643	0.576	0.154	0.537	0.484	0.675	0.236	0.751
APOB	r	0.156^S	0.002^P	0.220^S	0.386^**S	0.366^S	0.357^S	0.113^S	-0.116^S	0.190^S	0.050^S	-0.076^P	0.097^S
	p	0.101	0.990	0.080	0.007	0.079	0.095	0.449	0.590	0.386	0.740	0.723	0.661
TG	r	0.195^**P	0.019^P	0.272^**P	-0.05^P	-0.038^S	-0.069^P	-0.033^S	-0.076^S	0.006^S	0.213^**P	0.008^P	0.291^**P
	p	< 0.001	0.808	< 0.001	0.538	0.757	0.531	0.685	0.530	0.956	0.008	0.949	0.007
LPA	r	-0.001^P	-0.095^P	0.037^P	0.187^P	-0.149^S	0.177^P	0.082^S	0.164^S	-0.009^S	-0.126^P	-0.167^P	-0.203^P
	p	0.995	0.533	0.776	0.224	0.496	0.444	0.598	0.454	0.969	0.414	0.448	0.377
Hcy	r	0.056^P	0.067^P	0.043^P	-0.091^P	-0.245^*S	0.067^P	-0.130	-0.136^S	-0.093^S	0.060^P	0.096^P	0.040^P
	p	0.264	0.389	0.516	0.265	0.041	0.546	0.109	0.260	0.405	0.459	0.430	0.722
NEFA	r	0.029^P	0.112^P	-0.004^P	0.031^P	0.025^S	-0.023^P	0.108^S	0.140^S	0.091^S	0.238^**P	0.276^*P	0.199^P
	p	0.564	0.151	0.951	0.700	0.84	0.839	0.185	0.249	0.415	0.003	0.021	0.071
PLA2	r	0.105^S	0.102^P	0.144^S	0.393^S	0.319^P	0.418^S	-0.005^S	-0.606^*S	0.328^S	0.016^S	0.030^P	-0.150^S
	p	0.472	0.629	0.502	0.052	0.267	0.201	0.981	0.022	0.325	0.939	0.920	0.659

PC: platelet count, PDW: Platelet distribution width, MPV: Mean platelet volume, PCT: plateletcrit, Cho: cholesterol, HDL-C: high-density-lipoprotein cholesterol, LDL-C: low-density-lipoprotein cholesterol, ApoA1: apolipoprotein A-1, ApoB: apolipoprotein B, TG: triglyceride, LPA: lipoprotein A, Hcy: homocysteine, NEFA: non-esterified fatty acid, PLA2: phospholipase A2.
^S Spearman correlation analysis; ^P Pearson correlation analysis.
^*P < 0.05, ^** P < 0.01; P < 0.05 as significant difference, shown in bold font.

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ISSN: 1477-9560

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