Robust preimplantation genetic testing of the common F8 Inv22 pathogenic variant of severe hemophilia A using a highly polymorphic multi-marker panel encompassing the paracentric inversion

Table 1 Observed and expected heterozygosity values of 13 HEMA STR markers in the Vietnamese Kinh compared to the Chinese and Caucasions

Markers	Heterozygous	Total	Observed heterozygosity (H_o)			Expected heterozygosity (H_e)
Markers	Heterozygous	Total	VT	CH^a	CAU^a	VT	CH^a	CAU^a
DXS1073	127	153	0.83	0.73	0.51	0.86	0.69	0.66
REN90682	138	153	0.90	0.68	0.53	0.88	0.7	0.58
REN90833	89	153	0.58	0.49	0.43	0.85	0.49	0.43
F8Int25.2	116	153	0.76	0.50	0.47	0.61	0.48	0.51
F8Int22	112	153	0.73	0.52	0.55	0.76	0.51	0.56
F8Int21	111	153	0.73	0.48	0.51	0.81	0.48	0.51
F8Int13.2	105	151	0.70	0.63	0.57	0.85	0.58	0.65
F8Int1	110	153	0.72	0.45	0.43	0.77	0.48	0.49
stSG604486	107	147	0.73	0.59	0.51	0.87	0.54	0.52
HEMA154130.5	133	153	0.87	0.77	0.59	0.90	0.75	0.57
TMLHEInt2	131	153	0.86	0.63	0.67	0.88	0.60	0.65
TMLHEInt1.1	92	153	0.60	0.61	0.57	0.86	0.56	0.53
HEMA154498.9	124	153	0.81	0.84	0.78	0.90	0.77	0.79

VT Vietnamese Kinh, CH Singapore Chinese, CAU Coriell Cell Repositories Caucasian Human Variation Panel
^aFrom Zhao et al., 2017 [5]

ISSN: 1477-9560