Fig. 3
Scatter plots and funnel plots of the primary two-sample MR analyses (positive trait pairs). (A-D) In the scatter plots, the horizontal axis denotes the impact of instrumental variables (IVs) on the sex hormones, and the vertical axis represents the effect of IVs on VTE. Each black dots represents an individual SNP and the vertical and horizontal lines represent its corresponding 95% confidence interval (CI). The slope of the line represents the estimated causal effect of the various MR methods. (E-H) The horizontal axis of the funnel plot represents the estimated effect of each SNP on the exposure variable (βIV), while the vertical axis of 1/SEIV reflects the precision or uncertainty of these estimates. MR: Mendelian randomisation; SHBG: Sex hormone-binding globulin; TT: Total testosterone; VTE: Venous thromboembolism; PE: Pulmonary embolism; DVT: Deep vein thrombosis