Table 1 Pleiotropy and Heterogeneity Tests for the Primary Two-sample Mendelian Randomisation (MR) Analyses
| Â | Â | Pleiotropy test | Heterogeneity test | |||
|---|---|---|---|---|---|---|
Trait-pairs | Nsnp | Int | SE | P-value | Q-pval | Q |
SHBG-VTE | 148 | 0.004 | 0.003 | 0.229 | 0.000 | 219.144 |
TT-VTE | 138 | 0.003 | 0.003 | 0.221 | 0.000 | 231.745 |
BT-VTE | 86 | 0.003 | 0.004 | 0.532 | 0.000 | 135.675 |
SHBG-PE | 148 | 0.004 | 0.004 | 0.378 | 0.033 | 180.041 |
TT-PE | 140 | 0.006 | 0.003 | 0.093 | 0.001 | 196.25 |
BT-PE | 89 | 0.006 | 0.006 | 0.267 | 0.004 | 127.633 |
SHBG-DVT | 147 | 0.007 | 0.004 | 0.080 | 0.019 | 183.602 |
TT-DVT | 140 | 0.002 | 0.003 | 0.608 | 0.006 | 184.754 |
BT-DVT | 91 | 0.002 | 0.006 | 0.663 | 0.000 | 147.133 |