Skip to main content

Table 2 Genetic correlation and genetic overlap estimated by Linkage Disequilibrium Score regression (LDSC)

From: Causal inference of sex hormone-binding globulin on venous thromboembolism: evidence from Mendelian randomisation

 

Genetic correlation

Genetic overlap

Trait-pairs

Rg

Se

P-value

Beta

SE

P-value

SHBG-VTE

0.1067

0.0362

0.0032

0.0004

0.0080

0.9601

TT-VTE

0.0668

0.0377

0.0762

-0.0075

0.0055

0.1727

BT-VTE

0.0454

0.0431

0.2918

0.0019

0.0060

0.7515

SHBG-PE

0.1189

0.0487

0.0146

0.0004

0.0080

0.9601

TT-PE

0.0997

0.0479

0.0375

-0.0053

0.0056

0.3439

BT-PE

0.0537

0.0561

0.3384

0.0011

0.0053

0.8356

SHBG-DVT

0.1334

0.0417

0.0014

-0.0018

0.0077

0.8152

TT-DVT

0.0627

0.0426

0.1412

-0.0091

0.0059

0.1230

BT-DVT

0.0367

0.0507

0.4691

-0.0026

0.0058

0.6540

SHBG-VTE

0.1067

0.0362

0.0032

0.0004

0.0080

0.9601

  1. P-value ≤ 0.05 indicates that the assumptions of genetic association or genetic overlap hold true. Rg: Genetic correlation; SHBG: Sex hormone-binding globulin; TT: Total testosterone; BT: Bioactive testosterone; VTE: Venous thromboembolism; PE: Pulmonary embolism; DVT: Deep vein thrombosis.
Back to article page

Thrombosis Journal

ISSN: 1477-9560

Contact us