Table 1 Baseline characteristics of patients with atrial fibrillation stratified by different hemoglobin and platelet levels

Baseline characteristics

 Age (y), mean (SD)

64.6 ± 12.1

62.9 ± 11.9

68.7 ± 11.7

69.4 ± 10.6

 < 0.001

 Female, n (%)

2300 (42.1)

1517 (39.9)

726 (47.0)

57 (47.1)

 < 0.001

 Body weight(kg), mean (SD)

66.1 ± 12.2

67.7 ± 12.2

62.7 ± 11.5

58.9 ± 11.6

 < 0.001

 CHA2DS2-VASc score, mean (SD)

2.2 ± 1.6

2.0 ± 1.5

2.7 ± 1.6

2.3 ± 1.4

 < 0.001

 HAS-BLED score, mean (SD)

1.4 ± 1.0

1.3 ± 1.0

1.6 ± 1.0

1.5 ± 1.0

 < 0.001

Past medical history, n (%)

 COPD

109 (2.0)

53 (1.4)

52 (3.4)

4 (3.3)

 < 0.001

 Coronary heart disease

476 (8.7)

262 (6.9)

199 (12.9)

15 (12.4)

 < 0.001

 Congestive heart failure

278 (5.1)

141 (3.7)

122 (7.9)

15 (12.4)

 < 0.001

 Chronic kidney disease

338 (6.2)

195 (5.1)

132 (8.5)

11 (9.1)

 < 0.001

 Hypertension

2988 (54.6)

2016 (53.0)

921 (59.7)

51 (42.1)

 < 0.001

 Diabetes mellitus

1032 (18.9)

687 (18.1)

326 (21.1)

19 (15.7)

0.023

 Previous stroke

205 (3.7)

104 (2.7)

97 (6.3)

4 (3.3)

 < 0.001

 Gout

94 (1.7)

47 (1.2)

44 (2.8)

3 (2.5)

 < 0.001

 Malignancy

77 (1.4)

35 (0.9)

37 (2.4)

5 (4.1)

 < 0.001

Baseline laboratory data, mean(SD)

 ALT, IU/L

27.3 ± 40.0

27.7 ± 38.6

26.2 ± 43.7

27.6 ± 32.9

0.488

 CrCl, mL/min

74.3 ± 30.7

78.5 ± 30.4

65.0 ± 29.1

59.4 ± 28.5

 < 0.001

Baseline medications, n (%)

 Dabigatran

2548 (46.6)

1861 (48.9)

638 (41.3)

49 (40.5)

 < 0.001

   110 mg/bid

2469 (45.1)

1796 (47.2)

624 (40.4)

49 (40.5)

 < 0.001

   150 mg/bid

79 (1.4)

65 (1.7)

14 (0.9)

0 (0)

0.034

 Rivaroxaban

2921 (53.4)

1943 (51.1)

906 (58.7)

72 (59.5)

 < 0.001

   10 mg/qd

790 (14.4)

427 (11.2)

334 (21.6)

29 (24.0)

 < 0.001

   15 mg/qd

1986 (36.3)

1407 (37.0)

540 (35.0)

39 (32.2)

0.245

   20 mg/qd

145 (2.7)

109 (2.9)

32 (2.1)

4 (3.3)

0.237

 ACEI/ARB

2380 (43.5)

1659 (43.6)

677 (43.8)

44 (36.4)

0.272

 Amiodarone

962 (17.6)

714 (18.8)

229 (14.8)

19 (15.7)

0.002

 Beta-blocker

3484 (63.7)

2449 (64.4)

958 (62.0)

77 (63.6)

0.275

 CCB

1641 (30.0)

1152 (30.3)

456 (29.5)

33 (27.3)

0.693

 Diltiazem

768 (14.0)

529 (13.9)

224 (14.5)

15 (12.4)

0.738

 Digoxin

570 (10.4)

373 (9.8)

187 (12.1)

10 (8.3)

0.032

 Statins

2729 (49.9)

1872 (49.2)

789 (51.1)

68 (56.2)

0.171