Table 1 Baseline characteristics, comorbidities, and associated conditions stratified by thrombotic microangiopathy (TMA) in hospitalized patients
Characteristic | aHUS, N = 16 | infectious_related, N = 1,044 | pregnancy_related, N = 158 | malignancy, N = 628 | malignant_hypertension, N = 21 | STEC-HUS, N = 39 | transplant, N = 392 | TTP, N = 42 | p-value |
|---|---|---|---|---|---|---|---|---|---|
age | 38 (25, 42) | 63 (46, 74) | 33 (28, 39) | 62 (42, 73) | 51 (38, 65) | 4 (3, 13) | 56 (43, 64) | 53 (33, 63) | < 0.001 |
race | |||||||||
non-white | 3 (19%) | 147 (14%) | 21 (13%) | 66 (11%) | 3 (14%) | 2 (5.1%) | 71 (18%) | 7 (17%) | |
white | 13 (81%) | 897 (86%) | 137 (87%) | 562 (89%) | 18 (86%) | 37 (95%) | 321 (82%) | 35 (83%) | |
gender | < 0.001 | ||||||||
female | 9 (56%) | 487 (47%) | 158 (100%) | 286 (46%) | 11 (52%) | 22 (56%) | 175 (45%) | 28 (67%) | |
male | 7 (44%) | 557 (53%) | 0 (0%) | 342 (54%) | 10 (48%) | 17 (44%) | 217 (55%) | 14 (33%) | |
hypertension | 6 (38%) | 565 (54%) | 33 (21%) | 289 (46%) | 20 (95%) | 8 (21%) | 296 (76%) | 20 (48%) | < 0.001 |
hypertension_emergency | 0 (0%) | 6 (0.6%) | 0 (0%) | 0 (0%) | 21 (100%) | 0 (0%) | 0 (0%) | 0 (0%) | |
Unknown | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | |
diabetes | 1 (6.2%) | 378 (36%) | 5 (3.2%) | 185 (29%) | 10 (48%) | 5 (13%) | 133 (34%) | 8 (19%) | |
cardiovascular_disease | 0 (0%) | 83 (8.0%) | 0 (0%) | 21 (3.3%) | 6 (29%) | 1 (2.6%) | 18 (4.6%) | 2 (4.8%) | |
kidney_disease | 6 (38%) | 190 (18%) | 2 (1.3%) | 29 (4.6%) | 15 (71%) | 2 (5.1%) | 282 (72%) | 1 (2.4%) | |
liver_disease | 1 (6.2%) | 152 (15%) | 2 (1.3%) | 42 (6.7%) | 3 (14%) | 3 (7.7%) | 11 (2.8%) | 2 (4.8%) | |
transplant | 14 (88%) | 107 (10%) | 1 (0.6%) | 94 (15%) | 6 (29%) | 4 (10%) | 392 (100%) | 2 (4.8%) | |
pregnancy | 3 (19%) | 31 (3.0%) | 158 (100%) | 13 (2.1%) | 0 (0%) | 11 (28%) | 26 (6.6%) | 7 (17%) | |
Autoimmune_disease | 0 (0%) | 58 (5.6%) | 2 (1.3%) | 7 (1.1%) | 2 (9.5%) | 3 (7.7%) | 16 (4.1%) | 6 (14%) | |
malignancy | 0 (0%) | 186 (18%) | 1 (0.6%) | 628 (100%) | 0 (0%) | 4 (10%) | 6 (1.5%) | 6 (14%) | < 0.001 |
covid | 1 (6.2%) | 258 (25%) | 5 (3.2%) | 36 (5.7%) | 4 (19%) | 3 (7.7%) | 22 (5.6%) | 1 (2.4%) | |
infection | 2 (12%) | 1,044 (100%) | 0 (0%) | 0 (0%) | 0 (0%) | 15 (38%) | 0 (0%) | 0 (0%) | < 0.001 |
MAP | 107 (82, 109) | 87 (74, 97) | 103 (90, 113) | 89 (80, 99) | 117 (107, 128) | 77 (67, 94) | 110 (97, 120) | 87 (78, 100) | < 0.001 |