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Table 2 Univariate and multivariate analysis of factors associated with failed thromboprophylaxis

From: Factors associated with venous thromboembolic disease due to failed thromboprophylaxis

Variable

Univariate analysis

OR (95%CI) p value

Multivariate analysis

OR (95%CI) p value

BMI, kg/m2

1.05 (1.01–1.09)

0.011

1.04 (1.00-1.09)

0.039

Permanent central venous catheter

1.01 (0.44–2.31)

0.983

-

-

Active cancer

1.01 (0.68–1.48)

0.969

1.63 (1.03–2.57)

0.036

History of VTE

1.05 (0.39–2.85)

0.911

-

-

Indication for hospitalization i0

    

 Medic

 Non-orthopedic surgical Orthopedic Surgical

 Neurosurgery

Reference

0.77(0.46–1.30)

0.49 (0.21–1.14)

1.25 (0.35–4.49)

0.327

0.099

0.727

-

-

Surgery

0.82 (0.53–1.27)

0.371

-

-

Missed dose *

1.26 (0.88–1.81)

0.214

-

-

Leukocytosis

1.68 (1.23–2.53)

0.012

1.64 (1.05–2.57)

0.031

Transfusion of blood products

1.20 (0.78–1.84)

0.418

-

-

 No transfusion

 Packaged red blood cells

 Platelets

 Fresh frozen plasma

 Various

Referencia

1.32 (0.81–2.16)

0.41 (0.05–3.43)

0.99 (0.09–10.97)

1.09 (0.43–2-79

0.269

0.410

0.996

0.859

-

-

-

-

-

-

-

-

-

-

ICU requirement

3.31 (2.23–4.90)

< 0.001

3.67 (2.31–5.83)

< 0.001

Infection with SARS COV 2

1.97 (1.36–2,87)

< 0.001

-

-

  1. OR, Odds Ratio; CI, confidence interval; BMI, body mass index; VTE, venous thromboembolic disease; Leukocytosis, > 13,000 leukocytes/mm3; ICU, intensive care unit
  2. *Missed dose, 0 missed dose vs. ≥ 1 missed dose calculation was performed
  3. **Variables with p value > 0.05 in the univariate analysis were not included in the multivariate model
  4. *** AIC of the model 496.46, Nagelkerke’s pseudo R2 0.085